| Type | Description |
|---|---|
| Definition | SUMO peptidase family member, NEDD8 specific |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:31:00 | The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. | 31577950 |
| 2019-03-02 12:32:00 | Impairment of NEDDylation by Ubc12 knockout enhances PCNA ubiquitination and promotes PCNA-poleta interaction, while up-regulation of NEDDylation by NEDD8 overexpression or NEDP1 deletion reduces the excessive accumulation of ubiquitinated PCNA. Moreover, Ubc12 knockout decreases cell sensitivity to H2O2-induced oxidative stress, but NEDP1 deletion aggravates this sensitivity | 28831681 |
| 2018-02-10 11:31:00 | Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. | 28475037 |
| 2016-03-05 11:03:00 | In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8. | 25655932 |
| 2015-11-21 10:54:00 | the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. | 26403403 |
| Type | IDs |
|---|---|
| Synonymous | DEN1, NEDP1, PRSC2 |
| Gene |
UniProtKB-ID:
SENP8_HUMAN,
A8K8D3_HUMAN
UniprotKB:
Q96LD8,
A8K8D3
UniParc:
UPI00015DA9B2,
UPI0000135852
EMBL:
AF308450,
AY008293,
BC031411,
AK292298
Ensembl:
ENSG00000166192
KO:
hsa:123228
|
| Nucleutide sequences |
EMBL-CDS:
AAL06294.1,
AAG21828.1,
AAH31411.1,
BAF84987.1
Gene_ORFName:
FKSG8
Ensembl_TRS:
ENST00000340912,
ENST00000542035
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000340505,
ENSP00000446057
RefSeq:
NP_001159812.1,
NP_001165580.1,
XP_011519519.1,
NP_001165582.1,
NP_660205.3,
XP_005254214.1,
NP_001165581.1
|
| Others |
UniRef100:
UniRef100_A8K8D3,
UniRef100_Q96LD8
UniRef90:
UniRef90_Q96LD8
UniRef50:
UniRef50_Q96LD8
UniGene:
Hs.513002
CCDS:
CCDS10240.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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