| Type | Description |
|---|---|
| Definition | calcium channel, voltage-dependent, R type, alpha 1E subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:26:00 | Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression. | 30521978 |
| 2020-03-07 10:32:00 | Cav2.3 channels are regulators of nigral neuronal viability. Cav2.3 knockout reduced activity-associated nigral somatic Ca2+ signals and Ca2+-dependent after-hyperpolarizations, and afforded full protection from degeneration in vivo in a neurotoxin Parkinson's mouse model. Cav2.3 deficiency upregulated transcripts for NCS-1. Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3. | 31704946 |
| 2018-12-22 12:08:00 | The ex vivo neuronal setup of the isolated and superfused murine retina demonstrates a transient effect of bilirubin on neuronal signaling only when Cav2.3/R-type channels are present. Modulation of Cav2.3/R-type Ca2+ channels may contribute to the pathophysiological cascades of vasospasm or delayed cerebral ischemia. | 29274300 |
| 2018-05-05 11:50:00 | The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR-34c-5p. | 28614186 |
| 2016-06-04 10:30:00 | Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2+ Channel knockout (CaV2.3-/-) mice. | 26418566 |
| Type | IDs |
|---|---|
| Synonymous | A430040I15, BII, Cach6, Cacnl1a6, Cav2.3, Cchra1, alpha1E |
| Gene |
UniProtKB-ID:
A0A087WS83_MOUSE
UniprotKB:
A0A087WS83
UniParc:
UPI0000E6B146
EMBL:
AC101727,
AC112154,
AC099707,
AC119156,
AC122040
Ensembl:
ENSMUSG00000004110
KO:
mmu:12290
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000187541
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000140937
RefSeq:
XP_006529168.1,
XP_017168313.1,
XP_030100014.1,
XP_017168102.1,
NP_033912.2,
XP_017168284.1,
XP_017168171.1,
XP_017168201.1,
XP_036011834.1,
XP_017168117.1,
XP_017168131.1,
XP_011246218.1,
XP_011246211.1,
XP_017168234.1,
XP_017168108.1,
XP_017168219.1,
XP_017168255.1,
XP_017168337.1,
XP_030099789.1,
XP_030099786.1,
XP_017168149.1,
XP_017168067.1
|
| Others |
UniRef100:
UniRef100_A0A087WS83
UniRef90:
UniRef90_A0A087WS83
UniRef50:
UniRef50_O55017-2
UniGene:
Mm.267517
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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