| Type | Description |
|---|---|
| Definition | complement component 4 binding protein |
| Date | Results | Publications |
|---|---|---|
| 2017-09-30 14:12:00 | Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2) | 28542817 |
| 2017-07-01 12:52:00 | this study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production | 27794068 |
| 2015-11-21 11:22:00 | These results suggest that EpC4BP is involved in male reproduction, but not essential for sperm maturation. | 25468721 |
| 2010-01-21 00:00:00 | a novel function of C4BP as an epididymal secretory protein | 12930719 |
| 2010-01-21 00:00:00 | findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein | 15919903 |
| Type | IDs |
|---|---|
| Synonymous | AI195242, C4bpa |
| Gene |
UniProtKB-ID:
C4BPA_MOUSE
UniprotKB:
P08607
UniParc:
UPI00000228C3
EMBL:
AK149468,
M17122,
AK149477,
BC012257,
CH466520
Ensembl:
ENSMUSG00000026405
KO:
mmu:12269
|
| Nucleutide sequences |
EMBL-CDS:
EDL39738.1,
AAA37312.1,
BAE28899.1,
AAH12257.1,
BAE28904.1
Ensembl_TRS:
ENSMUST00000027657
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027657
RefSeq:
XP_011246208.1,
XP_017167981.1,
NP_031602.3
|
| Others |
UniRef100:
UniRef100_P08607
UniRef90:
UniRef90_P08607
UniRef50:
UniRef50_P08607
UniGene:
Mm.306720
CCDS:
CCDS35700.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 28542817 |
C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response. FEBS Lett. Naoko Morita , Tatsuya Yamazaki , Yusuke Murakami , Ryutaro Fukui , Ikuko Yamai , Isao Ichimonji , Akina Nakashima , Fumiaki Nagaoka , Hidekazu Takagi , Kensuke Miyake , Sachiko Akashi-Takamura |
2017-06-01 | - |
| 27794068 |
C4b binding protein negatively regulates TLR1/2 response. Innate Immun Naoko Morita , Ikuko Yamai , Koichiro Takahashi , Yutaka Kusumoto , Takuma Shibata , Toshihiko Kobayashi , Mayumi I Nonaka , Isao Ichimonji , Hidekazu Takagi , Kensuke Miyake , Sachiko A Takamura |
2017-01-01 | - |
| 25468721 |
Immunobiology Mayumi I Nonaka , Eva Zsigmond , Akihiko Kudo , Hayato Kawakami , Kaoru Yoshida , Manabu Yoshida , Natsuko Kawano , Kenji Miyado , Masaru Nonaka , Rick A Wetsel |
2015-04-01 |
C4bp
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21677750 |
A conditional knockout resource for the genome-wide study of mouse gene function. Nature William C Skarnes , Barry Rosen , Anthony P West , Manousos Koutsourakis , Wendy Bushell , Vivek Iyer , Alejandro O Mujica , Mark Thomas , Jennifer Harrow , Tony Cox , David Jackson , Jessica Severin , Patrick Biggs , Jun Fu , Michael Nefedov , Pieter J de Jong , A Francis Stewart , Allan Bradley |
2011-06-15 | - |
| 21267068 |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. Graciana Diez-Roux , Sandro Banfi , Marc Sultan , Lars Geffers , Santosh Anand , David Rozado , Alon Magen , Elena Canidio , Massimiliano Pagani , Ivana Peluso , Nathalie Lin-Marq , Muriel Koch , Marchesa Bilio , Immacolata Cantiello , Roberta Verde , Cristian De Masi , Salvatore A Bianchi , Juliette Cicchini , Elodie Perroud , Shprese Mehmeti , Emilie Dagand , Sabine Schrinner , Asja Nürnberger , Katja Schmidt , Katja Metz , Christina Zwingmann , Norbert Brieske , Cindy Springer , Ana Martinez Hernandez , Sarah Herzog , Frauke Grabbe , Cornelia Sieverding , Barbara Fischer , Kathrin Schrader , Maren Brockmeyer , Sarah Dettmer , Christin Helbig , Violaine Alunni , Marie-Annick Battaini , Carole Mura , Charlotte N Henrichsen , Raquel Garcia-Lopez , Diego Echevarria , Eduardo Puelles , Elena Garcia-Calero , Stefan Kruse , Markus Uhr , Christine Kauck , Guangjie Feng , Nestor Milyaev , Chuang Kee Ong , Lalit Kumar , MeiSze Lam , Colin A Semple , Attila Gyenesei , Stefan Mundlos , Uwe Radelof , Hans Lehrach , Paolo Sarmientos , Alexandre Reymond , Duncan R Davidson , Pascal Dollé , Stylianos E Antonarakis , Marie-Laure Yaspo , Salvador Martinez , Richard A Baldock , Gregor Eichele , Andrea Ballabio |
2011-01-18 | - |
| 18266273 |
Eur. J. Immunol. Patricia P Spijkers , Cécile V Denis , Anna M Blom , Peter J Lenting |
2008-03-01 |
C4bp,
Lrp1
|
| 17330941 |
Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. J. Proteome Res. Oliver K Bernhard , Eugene A Kapp , Richard J Simpson |
2007-03-01 |
Pzp,
Lyve1,
Cfd,
Ahsg,
Apoh,
Serpinc1,
Azgp1,
Serping1,
C4b,
C4bp,
Serpina6,
Cfh,
Cfi,
Clu,
Col1a1,
Cp,
Egfr,
Ces1c,
F13b,
F2,
Fn1,
Gc,
Gpld1,
Cfb,
H2-Q10,
Hc,
Igh-VJ558,
Itih1,
Itih2,
Klkb1,
Kng1,
Lum,
Mug1,
Orm1,
Pon1,
Apcs,
Serpina1a,
Serpina3k,
Serpina10,
Trf,
Ttr,
Vtn,
Afm,
Ighg2a,
Ighg3,
C1ra,
Hgfac,
Fetub,
Proz,
Cpn2,
IGHA2
|
| 16100035 |
Arterioscler. Thromb. Vasc. Biol. Cécile V Denis , Sarah J Roberts , Tilman M Hackeng , Peter J Lenting |
2005-10-01 |
C4bp,
PROS1
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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