Type | Description |
---|---|
Definition | BUB1B, mitotic checkpoint serine/threonine kinase |
Date | Results | Publications |
---|---|---|
2020-07-25 11:56:00 | BUBR1 allelic effects beyond protein level and aneuploidy contribute to disease heterogeneity in both Mosaic-variegated aneuploidy (MVA) patients and heterozygous carriers of MVA mutations. | 31738183 |
2020-02-08 11:38:00 | the ependymal cell layer does not form in the conditional knockout, revealing an unrecognized role of BubR1 in assuring the integrity of the ventricular system, which may account for the presence of hydrocephalus in some patients. | 30668728 |
2019-10-05 11:55:00 | the BubR1 signal is markedly elevated in metaphase kinetochores of oocytes with SETD2 depletion, indicative of the activation of spindle assembly checkpoint. In addition, we note that loss of SETD2 results in a drastic decrease in the trimethylation level of H3K36 in oocytes. Collectively, our data demonstrate that SETD2 is required for oocyte maturation and indicate a novel mechanism controlling the meiotic apparatus. | 30078214 |
2019-08-03 12:27:00 | that Sirt2-dependent BubR1 deacetylation involves in the regulation of meiotic apparatus in normal oocytes and mediates the effects of advanced maternal age on oocyte quality | 29067790 |
2018-08-04 10:18:00 | BubR1 insufficiency impairs angiogenesis and results in limb loss in ischemic hind limbs. | 28974341 |
Type | IDs |
---|---|
Synonymous | AU045529, BUBR1 |
Gene |
UniProtKB-ID:
BUB1B_MOUSE,
Q3UZD6_MOUSE
UniprotKB:
Q9Z1S0,
Q3UZD6
UniParc:
UPI00005ABA14,
UPI000019362B
EMBL:
AF107296,
AL845470,
AL929381,
AK133909
Ensembl:
ENSMUSG00000040084
KO:
mmu:12236
|
Nucleutide sequences |
EMBL-CDS:
AAD11940.1,
BAE21921.1
Ensembl_TRS:
ENSMUST00000038341
|
Protein sequencees |
Ensembl_PRO:
ENSMUSP00000037126
RefSeq:
NP_033903.2,
XP_006498685.1
|
Others |
UniRef100:
UniRef100_Q9Z1S0,
UniRef100_Q3UZD6
UniRef90:
UniRef90_Q9Z1S0
UniRef50:
UniRef50_O60566
UniGene:
Mm.29133
CCDS:
CCDS16579.1
|
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Refseq |
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