| Type | Description |
|---|---|
| Definition | BUB1, mitotic checkpoint serine/threonine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:30:00 | Bub1 insufficiency attenuates TF expression and reduces TM suppression by blocking Akt and JNK phosphorylation, respectively, thus leading to the prevention of ARF and death caused by sepsis. | 29608549 |
| 2016-04-09 10:53:00 | Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities. | 26031201 |
| 2013-02-23 11:24:00 | It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121. | 23209306 |
| 2011-09-24 11:49:00 | Results establish that Bub1 has oncogenic properties and suggest that Aurora B is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis. | 21646403 |
| 2010-05-31 11:53:00 | It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion. | 20124418 |
| Type | IDs |
|---|---|
| Synonymous | AL022991, Bub1a, C80208, D2Xrf87 |
| Gene |
UniProtKB-ID:
BUB1_MOUSE,
Q8K1K8_MOUSE,
A2APR8_MOUSE
UniprotKB:
O08901,
Q8K1K8,
A2APR8
UniParc:
UPI00000E6D5D,
UPI00001EF0DD,
UPI0000027D47
EMBL:
BC029116,
U89795,
AK144213,
AL844204,
AL844481,
AF002823
Ensembl:
ENSMUSG00000027379
KO:
mmu:12235
|
| Nucleutide sequences |
EMBL-CDS:
AAC53226.1,
AAC53533.1,
AAH29116.1,
BAE25776.1
Ensembl_TRS:
ENSMUST00000028858
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028858
RefSeq:
NP_001106650.1,
XP_036013667.1,
NP_033902.2,
XP_006498683.1
|
| Others |
UniRef100:
UniRef100_Q8K1K8,
UniRef100_A2APR8,
UniRef100_O08901
UniRef90:
UniRef90_O08901
UniRef50:
UniRef50_O08901
UniGene:
Mm.2185
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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