| Type | Description |
|---|---|
| Definition | Bruton agammaglobulinemia tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1beta-mediated colitis. | 31895698 |
| 2020-07-04 10:58:00 | Ibrutinib suppressed phosphorylation of BTK in neutrophils at lower doses and ITK in CD4+T cells at higher doses in CE-treated mice. | 31505252 |
| 2020-04-11 12:29:00 | Study utilized B cell-specific inositol polyphosphate multikinase (IPMK)-deficient mice to investigate the role of higher order inositol phosphates (InsP6) in B cell immunity and showed that IPMK is a regulator of T cell-independent immune responses and that InsP6 confers a mechanism to regulate the activity of Bruton's tyrosine kinase (Btk) in B cell receptor signaling. | 31189594 |
| 2020-04-04 10:30:00 | Performed crystallographic and biochemical analyses of Bruton agammaglobulinemia tyrosine kinase(Btk), which together show molecular details of its autoinhibition and activation. | 31076553 |
| 2019-12-14 11:31:00 | this study shows that Btk is required for maintaining lung vascular integrity during murine pneumococcal pneumosepsis | 30873567 |
| Type | IDs |
|---|---|
| Synonymous | AI528679, xid |
| Gene |
UniProtKB-ID:
BTK_MOUSE
UniprotKB:
P35991
UniParc:
UPI000002371A
EMBL:
L29788,
U58105,
L08967,
L10627
Ensembl:
ENSMUSG00000031264
KO:
mmu:12229
|
| Nucleutide sequences |
EMBL-CDS:
AAB47246.1,
AAA66943.1,
AAA37316.1
Ensembl_TRS:
ENSMUST00000033617
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033617
RefSeq:
NP_038510.2,
XP_006528546.1,
XP_006528548.1,
XP_006528547.1
|
| Others |
UniRef100:
UniRef100_P35991
UniRef90:
UniRef90_Q06187
UniRef50:
UniRef50_Q06187
UniGene:
Mm.4475
CCDS:
CCDS30396.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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