| Type | Description |
|---|---|
| Definition | signal peptide peptidase like 3 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-02 10:10:00 | Data suggest that activation of the metalloproteinase ADAM10 by signal peptide peptidase-like 3 (SPPL3) triggered by mutant BRAF(V600E) was a critical transformation event. | 28292959 |
| 2016-03-05 10:17:00 | Secretome analysis identifies novel signal Peptide peptidase-like 3 substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways | 25827571 |
| 2015-07-25 10:58:00 | Authors demonstrate that SPPL3 alters the pattern of cellular N-glycosylation by triggering the proteolytic release of active site-containing ectodomains of glycosidases and glycosyltransferases. | 25354954 |
| 2015-04-08 15:44:00 | SPPL3 cleaves Golgi type II membrane proteins leading to their secretion. SPPL3 substrates include Golgi glycosyltransferases MGAT5, B4GALT1, and B3GNT1. By facilitating disengagement of these glycosyltransferases from their membrane anchors, SPPL3 causes their premature secretion and consequently orchestrates the extent of N-glycosylation on human and murine cells. | 25354954 |
| 2015-04-08 15:44:00 | SPPL3 substrates identified on a proteome-wide scale in human and murine cells include numerous glycan-modifying enzymes residing in the Golgi network and implicated in distinct glycosylation pathways, including N-glycosylation, mucin-type O-glycosylation, O-mannosylation and glycosaminoglycan biosynthesis. | 25827571 |
| Type | IDs |
|---|---|
| Synonymous | IMP2, MDHV1887, PRO4332, PSH1, PSL4 |
| Gene |
UniProtKB-ID:
SPPL3_HUMAN,
Q9UG23_HUMAN
UniprotKB:
Q8TCT6,
Q9UG23
UniParc:
UPI000002B1BF,
UPI0000070AE4,
UPI0000013590
EMBL:
BC009551,
BC025781,
BC101625,
AK074916,
AL110147,
CH471054,
AJ420898,
AY169313,
AJ345030,
BC073910,
AB252457,
BC101627
Ensembl:
ENSG00000157837
KO:
hsa:121665
|
| Nucleutide sequences |
EMBL-CDS:
AAI01626.1,
BAF30928.1,
CAC87791.1,
AAH09551.1,
AAH25781.1,
AAI01628.1,
EAW98220.1,
CAD13135.1,
AAH73910.1,
BAC11290.1,
AAO12538.1,
CAB53661.1
Ensembl_TRS:
ENST00000353487
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000288680
RefSeq:
NP_620584.2,
XP_011536227.1
|
| Others |
UniRef100:
UniRef100_Q9UG23,
UniRef100_Q8TCT6
UniRef90:
UniRef90_Q8TCT6,
UniRef90_Q9UG23
UniRef50:
UniRef50_Q9UG23,
UniRef50_Q8TCT6
UniGene:
Hs.507087,
Hs.683964
CCDS:
CCDS9208.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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