| Type | Description |
|---|---|
| Definition | BCL2-interacting killer |
| Date | Results | Publications |
|---|---|---|
| 2018-01-27 11:52:00 | Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer. | 28986568 |
| 2017-07-01 13:03:00 | These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins. | 26437021 |
| 2017-02-04 11:21:00 | OPN induces oxidative stress via the involvement of mitochondria and NOX-4. It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK. | 27262843 |
| 2014-10-18 13:35:00 | Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis. | 25002530 |
| 2013-06-22 12:06:00 | Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. | 22388352 |
| Type | IDs |
|---|---|
| Synonymous | Biklk, Blk, Nbk |
| Gene |
UniProtKB-ID:
BIK_MOUSE
UniprotKB:
O70337
UniParc:
UPI00000214B4
EMBL:
AL583889,
CH467427,
AF048838
Ensembl:
ENSMUSG00000016758
KO:
mmu:12124
|
| Nucleutide sequences |
EMBL-CDS:
EDL01409.1,
AAC40079.1
Ensembl_TRS:
ENSMUST00000016902,
ENSMUST00000230912
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000016902,
ENSMUSP00000155083
RefSeq:
XP_006520419.1,
XP_006520417.1,
XP_006520418.1,
NP_031572.1,
XP_006520416.1
|
| Others |
UniRef100:
UniRef100_O70337
UniRef90:
UniRef90_O70337
UniRef50:
UniRef50_O70337
UniGene:
Mm.267006
CCDS:
CCDS27703.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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