| Type | Description |
|---|---|
| Definition | BRCA1 associated RING domain 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 11:12:00 | Results demonstrate that endometriotic cells inhibit BARD1/BRCA1 function by upregulating miR-210-3p, which might be the underlying mechanism for endometriotic cell maintenance of growth in oxidative stress. | 30760709 |
| 2019-04-20 11:29:00 | Bard1(S563F/S563F) and Bard1(K607A/K607A) mice, unlike Brca1(S1598F/S1598F) mice, are not tumor prone, indicating that homology-directed repair alone is sufficient to suppress tumor formation in the absence of stalled fork protection | 30244837 |
| 2019-04-13 11:58:00 | Study reports that USP15 affects cancer cell response to inhibitors by regulating homologous recombination repair. USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1. USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1gamma interaction, resulting in BRCA1/BARD1 retention at DSBs. Cancer-associated USP15 mutations, with decreased USP15-BARD1 interaction, increases Pduanyu37 inhibitor sensitivity. | 30874560 |
| 2016-07-16 11:29:00 | Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis. | 26415510 |
| 2010-01-21 00:00:00 | the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and homology-directed DNA repair. | 17848578 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
BARD1_MOUSE
UniprotKB:
O70445
UniParc:
UPI0000022822
EMBL:
BC128371,
BC128370,
AF057157
Ensembl:
ENSMUSG00000026196
KO:
mmu:12021
|
| Nucleutide sequences |
EMBL-CDS:
AAI28371.1,
AAC18095.1,
AAI28372.1
Ensembl_TRS:
ENSMUST00000027393
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027393
RefSeq:
XP_006495695.1,
NP_031551.1,
XP_006495694.1
|
| Others |
UniRef100:
UniRef100_O70445
UniRef90:
UniRef90_O70445
UniRef50:
UniRef50_Q99728
UniGene:
Mm.10764,
Mm.490738
CCDS:
CCDS15029.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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