| Type | Description |
|---|---|
| Definition | BTB and CNC homology, basic leucine zipper transcription factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:33:00 | BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. | 32515782 |
| 2020-10-24 14:02:00 | Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity. | 31552021 |
| 2020-06-20 12:27:00 | The findings suggest that Bach2-deficient autoreactive B cells preferentially react at extrafollicular sites to give rise to IgG class-switched pathogenic plasma cells and that this effect requires the help of Bach2(-)Icos(hi) helper T cells. | 31819031 |
| 2020-04-25 12:31:00 | Transcription regulator protein Bach2 prevents premature differentiation of suppressive effector Treg cells, limits IL-10 production and is required for the development of peripherally induced Treg cells in the gastrointestinal tract. Bach2 attenuates T-cell receptor (TCR) signaling-induced IRF4-dependent Treg cell differentiation. Bach2 counteracts the DNA-binding activity of IRF4 and limits chromatin accessibility. | 31937752 |
| 2020-01-04 12:12:00 | results demonstrate that Bach2 critically regulates Tfh cell differentiation and CD4(+) T cell memory. | 30971440 |
| Type | IDs |
|---|---|
| Synonymous | E030004N02Rik |
| Gene |
UniProtKB-ID:
BACH2_MOUSE
UniprotKB:
P97303
UniParc:
UPI000059DF0C,
UPI000059DF0B
EMBL:
BC131642,
AL831746,
D86604,
AL732547
Ensembl:
ENSMUSG00000040270
KO:
mmu:12014
|
| Nucleutide sequences |
EMBL-CDS:
AAI31643.1,
BAA13138.1
Ensembl_TRS:
ENSMUST00000108180,
ENSMUST00000037416,
ENSMUST00000171600
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000131592,
ENSMUSP00000043693,
ENSMUSP00000103815
RefSeq:
XP_030108972.1,
XP_011248212.1,
XP_006537629.1,
XP_036019500.1,
XP_036019501.1,
XP_006537630.1,
XP_011248211.1,
NP_001103131.1,
XP_011248210.1,
XP_030108969.1
|
| Others |
UniRef100:
UniRef100_P97303
UniRef90:
UniRef90_P97303
UniRef50:
UniRef50_Q9BYV9
UniGene:
Mm.491223
CCDS:
CCDS51135.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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