| Type | Description |
|---|---|
| Definition | chloride intracellular channel 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-17 10:27:00 | We have determined the crystal structure of soluble Clic2 from the euryhaline teleost fish Oreochromis mossambicus. Structural comparison of tilapia and human CLIC2 with other CLICs shows that these proteins are highly conserved. | 29198705 |
| 2013-06-22 11:24:00 | a vital role for the CLIC2 protein in maintaining normal cognitive function via its interaction with RyRs in the brain. | 22814392 |
| 2010-01-21 00:00:00 | Human CLIC2 was crystallized in 2 different forms, in presence of GSSH. Form A displayed P2(1)2(1)2(1) symmetry, with unit-cell parameters a=44.0, b=74.7, c=79.8 A. Form B displayed P2(1) symmetry, with unit-cell parameters a=36.0, b=66.9, c=44.1 A. | 18007051 |
| 2010-01-21 00:00:00 | CLIC2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles | 15147738 |
| 2010-01-21 00:00:00 | CLIC2 forms pH-dependent chloride channels in vitro with higher channel activity at low pH levels and that the channels are subject to redox regulation | 17945253 |
| Type | IDs |
|---|---|
| Synonymous | CLIC2b, MRXS32, XAP121 |
| Gene |
UniProtKB-ID:
CLIC2_HUMAN
UniprotKB:
O15247
UniParc:
UPI0000169FC8
EMBL:
AJ000219,
BC022305,
AK292785,
CH471172,
AJ000217,
Y12696,
AJ000218,
AL356738
Ensembl:
ENSG00000155962
KO:
hsa:1193
|
| Nucleutide sequences |
EMBL-CDS:
CAA73228.1,
BAF85474.1,
CAA03948.1,
AAH22305.1,
EAW72624.1,
CAI41464.1
Ensembl_TRS:
ENST00000369449
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000358460
RefSeq:
NP_001280.3
|
| Others |
UniRef100:
UniRef100_O15247
UniRef90:
UniRef90_O15247
UniRef50:
UniRef50_Q9QYB1
UniGene:
Hs.655445
CCDS:
CCDS14767.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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