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1187 CLCNKA

1187

CLCNKA

chloride voltage-gated channel Ka

protein-coding

Homo sapiens

基因描述

Type Description
Definition chloride voltage-gated channel Ka

研究结论

Date Results Publications
2020-12-26 13:12:00 Role of in the Regulation of the Human Kidney Chloride Channel ClC-Ka. 32581267
2019-01-19 10:43:00 Increasing expression of barttin over that of ClC-K partially recovered this insufficiency, indicating that N-terminal modifications of barttin alter both binding affinities and gating properties 29674316
2016-08-27 12:45:00 Single loci of tag of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk. 25919862
2015-10-03 10:44:00 R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity. 26013830
2014-10-04 10:06:00 HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved 24863058

名称对应

Type IDs
Synonymous CLCK1, ClC-K1, hClC-Ka
Gene
UniProtKB-ID: CLCKA_HUMAN
UniprotKB: P51800
UniParc: UPI0001AE77E5, UPI0000127993, UPI0000205CC5
EMBL: AL355994, BC053869, Z30643, U93878, BC048282, AK225550, AK298285
Ensembl: ENSG00000186510
KO: hsa:1187
Nucleutide sequences
EMBL-CDS: AAH48282.1, CAA83120.1, AAH53869.1, AAB65148.1, BAG60545.1
Ensembl_TRS: ENST00000331433, ENST00000439316, ENST00000375692
Protein sequencees
Ensembl_PRO: ENSP00000332771, ENSP00000364844, ENSP00000414445
RefSeq: NP_001244068.1, NP_001036169.1, NP_004061.3
Others
UniRef100: UniRef100_P51800
UniRef90: UniRef90_P51800
UniRef50: UniRef50_P51800
UniGene: Hs.591533
CCDS: CCDS167.1, CCDS41269.1, CCDS57973.1

全选

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