| Type | Description |
|---|---|
| Definition | Araf proto-oncogene, serine/threonine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:08:00 | DA-Raf1 (DA-Raf) is a splicing variant of A-Raf that suppresses the Ras-ERK pathway and is essential for both myocyte differentiation including myoblast fusion and apoptosis but apoptosis is not a prerequisite for myoblast fusion | 30742807 |
| 2018-05-19 12:01:00 | PKM1 interacts with A-Raf, an upstream regulator of the MEK/ERK pathway, and that this interaction contributes to MEK1 phosphorylation by A-Raf. | 28743549 |
| 2017-06-24 10:31:00 | A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability. | 28073913 |
| 2017-05-27 10:54:00 | A-Raf promotes osteoblasts differentiation in response to mechanical stress. | 27240957 |
| 2014-08-23 10:37:00 | DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in alveolar epithelial 2 cells is required for alveolar formation via triggering MMP2 activation followed by myofibroblast differentiation. | 24843139 |
| Type | IDs |
|---|---|
| Synonymous | 1200013E08Rik, A-Raf, AW495444, Araf1 |
| Gene |
UniProtKB-ID:
ARAF_MOUSE,
Q8CAD1_MOUSE
UniprotKB:
P04627,
Q8CAD1
UniParc:
UPI00000E9636,
UPI0000027DF2
EMBL:
AK039044,
D00024,
AK020547,
AK133797,
AL671885,
AK004741,
AB158252,
AK010060,
BC004757
Ensembl:
ENSMUSG00000001127
KO:
mmu:11836
|
| Nucleutide sequences |
EMBL-CDS:
BAB32131.3,
BAA00018.1,
BAB26674.1,
BAB23522.1,
AAH04757.1,
BAE21848.1,
BAE66643.1,
BAC30217.1
Ensembl_TRS:
ENSMUST00000001155,
ENSMUST00000122312,
ENSMUST00000120356
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000001155,
ENSMUSP00000112521,
ENSMUSP00000112513
RefSeq:
XP_030107064.1,
XP_006527619.1,
XP_006527620.1,
XP_011245731.2,
NP_033833.1,
NP_001153117.1
|
| Others |
UniRef100:
UniRef100_Q8CAD1,
UniRef100_P04627
UniRef90:
UniRef90_A0A384C7V2,
UniRef90_P14056
UniRef50:
UniRef50_P14056,
UniRef50_F1QBH1
UniGene:
Mm.220946
CCDS:
CCDS40886.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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