| Type | Description |
|---|---|
| Definition | apolipoprotein C-III |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:07:00 | data indicate that apoE determines the metabolic impact of apoC-III as we establish that apoE is essential to mediate inhibition of TRL clearance by apoC-III and that, in the absence of functional apoE, apoC-III inhibits tissue LPL activity. | 31092690 |
| 2020-06-20 10:14:00 | observations demonstrate that relative insulin deficiency increases APOC3 and that this results in elevated levels of TRLs and accelerated atherosclerosis in a mouse model of T1DM. | 31295146 |
| 2018-12-22 11:55:00 | Both triglyceride-rich lipoproteins (TRLs) and ApoCIII contribute to the progression of atherosclerosis, and the modulation of TRLs and ApoCIII may represent a novel therapeutic approach against hypertriglyceridemia induced atherosclerosis. | 30223835 |
| 2018-06-23 11:21:00 | C3(QK) variant is a gain-of-function mutation that can stimulate VLDL1 production, through enhanced DNL | 28887372 |
| 2017-12-23 11:53:00 | intestinal apoC-III overexpression results in the secretion of smaller, less dense chylomicron particles along with reduced triacylglycerol secretion from the intestine | 28159868 |
| Type | IDs |
|---|---|
| Synonymous | apo-CIII, apoC-III |
| Gene |
UniProtKB-ID:
APOC3_MOUSE,
E9QP56_MOUSE,
A0A0R4J1N3_MOUSE
UniprotKB:
P33622,
E9QP56,
A0A0R4J1N3
UniParc:
UPI00000E84B5,
UPI0000023992,
UPI000164C362
EMBL:
AK008260,
L04150,
AK002908,
AC116503,
L04149,
BC021776
Ensembl:
ENSMUSG00000032081
KO:
mmu:11814
|
| Nucleutide sequences |
EMBL-CDS:
BAB25563.1,
AAH21776.1,
BAB22448.1
Ensembl_TRS:
ENSMUST00000121916,
ENSMUST00000118649,
ENSMUST00000034586
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000113126,
ENSMUSP00000034586,
ENSMUSP00000113058
RefSeq:
NP_001276684.1,
NP_001276762.1,
NP_075603.1,
NP_001276685.1
|
| Others |
UniRef100:
UniRef100_E9QP56,
UniRef100_P33622
UniRef90:
UniRef90_P33622,
UniRef90_E9QP56
UniRef50:
UniRef50_P06759,
UniRef50_P02656
UniGene:
Mm.390161
CCDS:
CCDS23141.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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