| Type | Description |
|---|---|
| Definition | baculoviral IAP repeat-containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 10:07:00 | IAP inhibition or loss of both cIAP2 and XIAP resulted in a strong blockage in autophagic flux and mitophagy, suggesting that XIAP deficiency may also drive Crohn's Disease due to defects in autophagy. | 29743550 |
| 2019-01-05 10:46:00 | Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation. | 29191979 |
| 2018-04-07 11:15:00 | These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations. | 28723569 |
| 2018-02-24 11:10:00 | These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1. | 28542143 |
| 2017-12-23 10:49:00 | Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha. | 27129149 |
| Type | IDs |
|---|---|
| Synonymous | AW107670, Api1, Api2, Birc2, C-IAP2, HIAP2, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF49, cIAP-1, cIAP-2, cIAP1, cIAP2 |
| Gene |
UniProtKB-ID:
BIRC3_MOUSE,
Q3TSE5_MOUSE,
A2CGA5_MOUSE
UniprotKB:
O08863,
Q3TSE5,
A2CGA5
UniParc:
UPI00001F6E0C,
UPI00005B1E0A,
UPI00000212DF
EMBL:
U88908,
AK162108,
CT030639
Ensembl:
ENSMUSG00000032000
KO:
mmu:11796
|
| Nucleutide sequences |
EMBL-CDS:
AAC53531.1,
BAE36730.1
Ensembl_TRS:
ENSMUST00000013949
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000013949
RefSeq:
XP_006509892.1,
XP_006509894.1,
NP_031490.2,
XP_011240655.1,
XP_006509891.1,
XP_036010464.1,
XP_011240654.1,
XP_006509893.1
|
| Others |
UniRef100:
UniRef100_O08863,
UniRef100_Q3TSE5
UniRef90:
UniRef90_O08863
UniRef50:
UniRef50_Q13489
UniGene:
Mm.2026
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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