| Type | Description |
|---|---|
| Definition | tripartite motif containing 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:15:00 | TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1. | 31992359 |
| 2020-06-13 10:13:00 | these results provide evidence that TRIM6 contributes to the antiviral response against WNV and identify VAMP8 as a novel regulator of the IFN-I system. | 31694946 |
| 2017-09-02 11:52:00 | Intriguingly, the authors also found that TRIM6 enhances ebola virus polymerase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious ebola virus, suggesting that VP35 hijacks TRIM6 to promote ebola virus replication through ubiquitination. | 28679761 |
| 2017-06-24 12:27:00 | Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains. | 27622505 |
| 2014-09-06 11:00:00 | TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKepsilon for subsequent phosphorylation. | 24882218 |
| Type | IDs |
|---|---|
| Synonymous | RNF89 |
| Gene |
UniProtKB-ID:
TRIM6_HUMAN
UniprotKB:
Q9C030
UniParc:
UPI00001373F4,
UPI0000EE37E8,
UPI000041A255
EMBL:
CH471064,
AC015691,
BC047564,
AK298301,
AB039903,
AK290172,
AK316178,
AK293295,
AK027664,
AK316289,
AF220030
Ensembl:
ENSG00000121236
KO:
hsa:117854
|
| Nucleutide sequences |
EMBL-CDS:
AAH47564.1,
BAH14549.1,
BAB17050.1,
BAB55276.1,
AAG53484.1,
BAH14660.1,
EAW68783.1,
EAW68785.1,
BAG60556.1,
BAG56816.1,
BAF82861.1
Ensembl_TRS:
ENST00000507320,
ENST00000445329,
ENST00000506134,
ENST00000515022,
ENST00000278302,
ENST00000380097
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000278302,
ENSP00000369440,
ENSP00000427704,
ENSP00000421802,
ENSP00000399215,
ENSP00000421079
RefSeq:
NP_477514.1,
NP_001003818.1,
NP_001185574.1,
NP_001185573.1
|
| Others |
UniRef100:
UniRef100_Q9C030
UniRef90:
UniRef90_Q9C030
UniRef50:
UniRef50_Q9C030
UniGene:
Hs.729048
CCDS:
CCDS31390.1,
CCDS55738.1,
CCDS31389.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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