| Type | Description |
|---|---|
| Definition | ring finger and FYVE like domain containing E3 ubiquitin protein ligase |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 13:23:00 | The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors. | 30659120 |
| 2019-04-13 12:04:00 | RFFL is an important regulator of voltage-gated hERG potassium channel activity and therefore cardiac repolarization and that this ubiquitination-mediated regulation requires parts of the ERAD pathway. | 30401747 |
| 2017-09-23 12:30:00 | it is interesting to note that a human lncRNA does exist within the 5'-UTR intronic region of the human RFFL gene . Given the rat data, our study may serve as a translational foundation for considering this human lncRNA as a candidate regulator for cardiovascular diseases. | 28827789 |
| 2014-02-08 10:33:00 | EGF, which signals through CRAF, and an activated BRAF mutant also activate and stimulate cell migration through up-regulating RFFL expression. | 24114843 |
| 2011-08-06 11:02:00 | data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of mRNAs in a p53-independent manner. | 21308745 |
| Type | IDs |
|---|---|
| Synonymous | CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L |
| Gene |
UniProtKB-ID:
RFFL_HUMAN
UniprotKB:
Q8WZ73
UniParc:
UPI000013FA60,
UPI000006D9BA,
UPI000006D6B9
EMBL:
BC015681,
AK093112,
CH471147,
CR933651,
BC028424,
AY098935,
AF434816
Ensembl:
ENSG00000092871
KO:
hsa:117584
|
| Nucleutide sequences |
EMBL-CDS:
EAW80176.1,
EAW80173.1,
AAM29181.1,
BAC04059.1,
AAL30771.1,
EAW80178.1,
EAW80177.1,
CAI45952.1,
EAW80172.1,
AAH15681.2,
AAH28424.1
Ensembl_TRS:
ENST00000415395,
ENST00000394597,
ENST00000315249,
ENST00000584655,
ENST00000447669,
ENST00000413582
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000408513,
ENSP00000326170,
ENSP00000463035,
ENSP00000378096,
ENSP00000412322,
ENSP00000389832
RefSeq:
NP_001017368.1
|
| Others |
UniRef100:
UniRef100_Q8WZ73
UniRef90:
UniRef90_Q8WZ73
UniRef50:
UniRef50_Q8WZ73
UniGene:
Hs.13680
CCDS:
CCDS11286.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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