| Type | Description |
|---|---|
| Definition | methionine adenosyltransferase I, alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:22:00 | a critical role of MATalpha1 in regulating mitochondrial function by suppressing CYP2E1 expression at multiple levels. | 31077594 |
| 2019-12-21 12:37:00 | The reproduction of these changes in MAT1A-KO mice, prone to develop hepatitis and HCC, demonstrates the pathogenetic role of MAT1A gene under-regulation associated with up-regulation of the MAT2A gene (MAT1A:MAT2A switch), encoding the SAM synthesizing enzymes, methyladenosyltransferase I/III (MATI/III) and methyladenosyltransferase II (MATII), respectively. This leads to a rise of MATII, inhibited by the reaction produc | 31234428 |
| 2019-04-27 10:07:00 | The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch. | 29749642 |
| 2017-07-22 13:17:00 | interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis | 26969892 |
| 2012-02-11 10:58:00 | MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice. | 21837751 |
| Type | IDs |
|---|---|
| Synonymous | AI046368, AdoMet, Ams, MAT, MATA1, SAMS, SAMS1 |
| Gene |
UniProtKB-ID:
METK1_MOUSE
UniprotKB:
Q91X83
UniParc:
UPI0000026748
EMBL:
BC011211,
AK153832,
AK149542
Ensembl:
ENSMUSG00000037798
KO:
mmu:11720
|
| Nucleutide sequences |
EMBL-CDS:
BAE28947.1,
BAE32202.1,
AAH11211.1
Ensembl_TRS:
ENSMUST00000047286,
ENSMUST00000225720
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000044288,
ENSMUSP00000153488
RefSeq:
NP_598414.1,
XP_006518513.1
|
| Others |
UniRef100:
UniRef100_Q91X83
UniRef90:
UniRef90_P13444
UniRef50:
UniRef50_P13444
UniGene:
Mm.14064,
Mm.486779
CCDS:
CCDS26959.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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