| Type | Description |
|---|---|
| Definition | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-20 11:02:00 | In this review, we summarize current knowledge about the WFIKKN proteins and propose that they are "companion" proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad and non-Smad pathways by TGFB. | 27325460 |
| 2017-07-01 11:19:00 | Data show that the KKN1 fragment generated by BMP1-cleavage of WFIKKN1 protein contributes most significantly to the observed enhancer activity. | 27782377 |
| 2013-10-26 14:05:00 | Data suggest that myostatin binding to its receptor (activin receptors type II) can be blocked by WFIKKN1 but not WFIKKN2; various forms of myostatin (promyostatin, myostatin pro-domain, and latent/processed myostatin) bind WFIKKN1 but not WFIKKN2. | 23829672 |
| 2011-01-15 10:49:00 | data indicate that WFIKKN proteins are antagonists of GDF8 and GDF11, but in the case of TGFbeta1, BMP2 and BMP4 they function as growth factor binding proteins | 21054789 |
| 2010-01-21 00:00:00 | Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. | 18596030 |
| Type | IDs |
|---|---|
| Synonymous | C16orf12, RJD2, WFDC20A, WFIKKN |
| Gene |
UniProtKB-ID:
WFKN1_HUMAN
UniprotKB:
Q96NZ8
UniParc:
UPI0000043725
EMBL:
AE006464,
AF422194,
BC101606,
AK075356,
BC101602
Ensembl:
ENSG00000127578
KO:
hsa:117166
|
| Nucleutide sequences |
EMBL-CDS:
AAL18839.1,
AAI01607.1,
AAI01603.1,
AAK61237.1,
BAC11566.1
Gene_ORFName:
PSEC0040
Ensembl_TRS:
ENST00000319070
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000324763
RefSeq:
NP_444514.1
|
| Others |
UniRef100:
UniRef100_Q96NZ8
UniRef90:
UniRef90_Q96NZ8
UniRef50:
UniRef50_Q96NZ8
UniGene:
Hs.345818
CCDS:
CCDS10414.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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