| Type | Description |
|---|---|
| Definition | SH2 domain containing 1B |
| Date | Results | Publications |
|---|---|---|
| 2017-02-18 11:16:00 | When compared with SAP, the other single SH2 domain protein in human, EAT2 shows similar binding energies to unphosphorylated ligands. This is inconsistent to the previous data showing low affinity of EAT2 toward unphosphorylated peptides compared to SAP which shows high affinity | 27586300 |
| 2014-12-20 10:44:00 | Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets. | 24374770 |
| 2014-05-31 11:25:00 | EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase. | 24687958 |
| 2010-01-21 00:00:00 | NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2 | 16920955 |
| Type | IDs |
|---|---|
| Synonymous | EAT2 |
| Gene |
UniProtKB-ID:
SH21B_HUMAN
UniprotKB:
O14796
UniParc:
UPI0000204C75,
UPI00000015D1
EMBL:
AF256653,
AF020264,
AF484964,
BC022407,
AF403479,
AK314743,
BC066595,
AK097162,
AL512785,
CH471067
Ensembl:
ENSG00000198574
KO:
hsa:117157
|
| Nucleutide sequences |
EMBL-CDS:
AAH66595.1,
BAC04968.1,
AAL26000.1,
EAW90703.1,
BAG37283.1,
AAL27357.1,
AAB70927.1,
AAM28522.1,
AAH22407.1
Ensembl_TRS:
ENST00000367929
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356906
RefSeq:
NP_444512.2
|
| Others |
UniRef100:
UniRef100_O14796
UniRef90:
UniRef90_O14796
UniRef50:
UniRef50_O14796
UniGene:
Hs.350581
CCDS:
CCDS30928.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32814053 |
Cell Rep Christian Haenig , Nir Atias , Alexander K Taylor , Arnon Mazza , Martin H Schaefer , Jenny Russ , Sean-Patrick Riechers , Shushant Jain , Maura Coughlin , Jean-Fred Fontaine , Brian D Freibaum , Lydia Brusendorf , Martina Zenkner , Pablo Porras , Martin Stroedicke , Sigrid Schnoegl , Kristin Arnsburg , Annett Boeddrich , Lucia Pigazzini , Peter Heutink , J Paul Taylor , Janine Kirstein , Miguel A Andrade-Navarro , Roded Sharan , Erich E Wanker |
2020-08-18 | - |
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 27586300 |
The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett. Mohammed Taha , Eric Nezerwa , Hyun-Joo Nam |
2016-01-01 | - |
| 25814554 |
Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. Arndt Grossmann , Nouhad Benlasfer , Petra Birth , Anna Hegele , Franziska Wachsmuth , Luise Apelt , Ulrich Stelzl |
2015-03-01 |
SH2B3,
SH2D3A,
HUWE1,
FSBP,
TSPAN2,
TNK2,
SPRY2,
APBB3,
TRDN,
ANAPC10,
BAIAP2,
ZNHIT1,
SEMA4D,
UBD,
CENPB,
POLR3F,
RAI2,
SDCCAG8,
FRS3,
FRS2,
PGRMC1,
CYP46A1,
ARID5A,
NMU,
RALBP1,
YWHAQ,
LECT1,
CYB561D2,
RCAN3,
CAPN10,
FSTL1,
RASSF1,
CHN2,
TP53RK,
EFHC1,
OSBPL6,
C1QTNF3,
DDIT4L,
FAM46B,
CKM,
TM4SF19,
RBP7,
OLIG1,
CLNK,
SH2D1B,
TWIST2,
ASCL4,
SOCS4,
COX6B2,
GABPB2,
SHE,
VSTM2L,
C22orf39,
PPP1R21,
SCLT1,
PACRGL,
SETD9,
C6orf141,
MAGEC3,
DCAF12L1,
CRK,
CRKL,
CRP,
TCP10L,
ASB8,
ASB9,
CRYBA2,
CSK,
DUSP18,
FAM117B,
PLB1,
IQUB,
WBSCR27,
CYP2C8,
DBN1,
PAQR7,
DDX5,
LIX1,
GLIS3,
DOK1,
EPYC,
DTNA,
E2F2,
E2F6,
PHC2,
KRTCAP2,
ELK1,
ADCK5,
EPS8,
AKT1,
ESD,
MECOM,
EYA3,
EZH2,
FABP7,
FANCG,
MPEG1,
LNX2,
FAM217A
|
| 25416956 |
A proteome-scale map of the human interactome network. Cell Thomas Rolland , Murat TaÅan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal |
2014-11-20 | - |
| 24952745 |
Nat. Genet. Dan E Arking , Sara L Pulit , Lia Crotti , Pim van der Harst , Patricia B Munroe , Tamara T Koopmann , Nona Sotoodehnia , Elizabeth J Rossin , Michael Morley , Xinchen Wang , Andrew D Johnson , Alicia Lundby , DanÃel F Gudbjartsson , Peter A Noseworthy , Mark Eijgelsheim , Yuki Bradford , Kirill V Tarasov , Marcus Dörr , Martina Müller-Nurasyid , Annukka M Lahtinen , Ilja M Nolte , Albert Vernon Smith , Joshua C Bis , Aaron Isaacs , Stephen J Newhouse , Daniel S Evans , Wendy S Post , Daryl Waggott , Leo-Pekka Lyytikäinen , Andrew A Hicks , Lewin Eisele , David Ellinghaus , Caroline Hayward , Pau Navarro , Sheila Ulivi , Toshiko Tanaka , David J Tester , Stéphanie Chatel , Stefan Gustafsson , Meena Kumari , Richard W Morris , à sa T Naluai , Sandosh Padmanabhan , Alexander Kluttig , Bernhard Strohmer , Andrie G Panayiotou , Maria Torres , Michael Knoflach , Jaroslav A Hubacek , Kamil Slowikowski , Soumya Raychaudhuri , Runjun D Kumar , Tamara B Harris , Lenore J Launer , Alan R Shuldiner , Alvaro Alonso , Joel S Bader , Georg Ehret , Hailiang Huang , W H Linda Kao , James B Strait , Peter W Macfarlane , Morris Brown , Mark J Caulfield , Nilesh J Samani , Florian Kronenberg , Johann Willeit , CARe Consortium , COGENT Consortium , J Gustav Smith , Karin H Greiser , Henriette Meyer Zu Schwabedissen , Karl Werdan , Massimo Carella , Leopoldo Zelante , Susan R Heckbert , Bruce M Psaty , Jerome I Rotter , Ivana Kolcic , Ozren PolaÅ¡ek , Alan F Wright , Maura Griffin , Mark J Daly , DCCT/EDIC , David O Arnar , Hilma Hólm , Unnur Thorsteinsdottir , eMERGE Consortium , Joshua C Denny , Dan M Roden , Rebecca L Zuvich , Valur Emilsson , Andrew S Plump , Martin G Larson , Christopher J O'Donnell , Xiaoyan Yin , Marco Bobbo , Adamo P D'Adamo , Annamaria Iorio , Gianfranco Sinagra , Angel Carracedo , Steven R Cummings , Michael A Nalls , Antti Jula , Kimmo K Kontula , Annukka Marjamaa , Lasse Oikarinen , Markus Perola , Kimmo Porthan , Raimund Erbel , Per Hoffmann , Karl-Heinz Jöckel , Hagen Kälsch , Markus M Nöthen , HRGEN Consortium , Marcel den Hoed , Ruth J F Loos , Dag S Thelle , Christian Gieger , Thomas Meitinger , Siegfried Perz , Annette Peters , Hanna Prucha , Moritz F Sinner , Melanie Waldenberger , Rudolf A de Boer , Lude Franke , Pieter A van der Vleuten , Britt Maria Beckmann , Eimo Martens , Abdennasser Bardai , Nynke Hofman , Arthur A M Wilde , Elijah R Behr , Chrysoula Dalageorgou , John R Giudicessi , Argelia Medeiros-Domingo , Julien Barc , Florence Kyndt , Vincent Probst , Alice Ghidoni , Roberto Insolia , Robert M Hamilton , Stephen W Scherer , Jeffrey Brandimarto , Kenneth Margulies , Christine E Moravec , Fabiola del Greco M , Christian Fuchsberger , Jeffrey R O'Connell , Wai K Lee , Graham C M Watt , Harry Campbell , Sarah H Wild , Nour E El Mokhtari , Norbert Frey , Folkert W Asselbergs , Irene Mateo Leach , Gerjan Navis , Maarten P van den Berg , Dirk J van Veldhuisen , Manolis Kellis , Bouwe P Krijthe , Oscar H Franco , Albert Hofman , Jan A Kors , André G Uitterlinden , Jacqueline C M Witteman , Lyudmyla Kedenko , Claudia Lamina , Ben A Oostra , Gonçalo R Abecasis , Edward G Lakatta , Antonella Mulas , Marco Orrú , David Schlessinger , Manuela Uda , Marcello R P Markus , Uwe Völker , Harold Snieder , Timothy D Spector , Johan Ãrnlöv , Lars Lind , Johan Sundström , Ann-Christine Syvänen , Mika Kivimaki , Mika Kähönen , Nina Mononen , Olli T Raitakari , Jorma S Viikari , Vera Adamkova , Stefan Kiechl , Maria Brion , Andrew N Nicolaides , Bernhard Paulweber , Johannes Haerting , Anna F Dominiczak , Fredrik Nyberg , Peter H Whincup , Aroon D Hingorani , Jean-Jacques Schott , Connie R Bezzina , Erik Ingelsson , Luigi Ferrucci , Paolo Gasparini , James F Wilson , Igor Rudan , Andre Franke , Thomas W Mühleisen , Peter P Pramstaller , Terho J Lehtimäki , Andrew D Paterson , Afshin Parsa , Yongmei Liu , Cornelia M van Duijn , David S Siscovick , Vilmundur Gudnason , Yalda Jamshidi , Veikko Salomaa , Stephan B Felix , Serena Sanna , Marylyn D Ritchie , Bruno H Stricker , Kari Stefansson , Laurie A Boyer , Thomas P Cappola , Jesper V Olsen , Kasper Lage , Peter J Schwartz , Stefan Kääb , Aravinda Chakravarti , Michael J Ackerman , Arne Pfeufer , Paul I W de Bakker , Christopher Newton-Cheh |
2014-08-01 | - |
| 24728074 |
Mol Cell Proteomics Kin K Leung , Ronald J Hause , John L Barkinge , Mark F Ciaccio , Chih-Pin Chuu , Richard B Jones |
2014-07-01 | - |
| 24374770 |
Int. Immunol. Yasser A Aldhamen , Sergey S Seregin , Charles F Aylsworth , Sarah Godbehere , Andrea Amalfitano |
2014-05-01 |
SH2D1B
|
| 24687958 |
J Exp Med Luis-Alberto Pérez-Quintero , Romain Roncagalli , Huaijian Guo , Sylvain Latour , Dominique Davidson , André Veillette |
2014-04-07 | - |
| 24642916 |
Fine specificity and molecular competition in SLAM family receptor signalling. PLoS ONE Timothy J Wilson , Lee I Garner , Clive Metcalfe , Elliott King , Stefanie Margraf , Marion H Brown |
2014-01-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员