| Type | Description |
|---|---|
| Definition | toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 10:09:00 | GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. | 30332431 |
| 2018-06-09 10:22:00 | independently down-regulated CXCL2 and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine receptors (CXCR1 and CXCR2) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints. | 27995997 |
| 2018-03-17 10:38:00 | Our key findings provide novel insights into the mechanism of action of heterotrimeric complex in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages. | 28528205 |
| 2017-11-18 12:45:00 | Results suggest that TIR domain-containing adaptor protein positively regulated BV2 microglial M1 polarization through toll-like receptor 4 -mediated Transforming Growth Factor-Beta-Activated Kinase 1/I-Kappa-B Kinase /Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells (TAK1/IKK/NF-kappaB), mitogen-activated protein kinases and Akt signalling pathways. | 27061018 |
| 2017-06-03 10:53:00 | The adapter Mal (encoded by TIRAP) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9. | 27646001 |
| Type | IDs |
|---|---|
| Synonymous | AA407980, C130027E04Rik, Mal, Tlr4ap, Wyatt |
| Gene |
UniProtKB-ID:
TIRAP_MOUSE,
Q3UB38_MOUSE,
Q542S6_MOUSE,
H3BKL1_MOUSE
UniprotKB:
Q99JY1,
Q3UB38,
Q542S6,
H3BKL1
UniParc:
UPI00005ACAA2,
UPI0000003FF7,
UPI000154889A,
UPI0000027A99
EMBL:
AF410784,
AC140448,
BC005584,
AK151117,
AK080135,
AF378130,
AK168494,
AK036431
Ensembl:
ENSMUSG00000032041
KO:
mmu:117149
|
| Nucleutide sequences |
EMBL-CDS:
AAL05628.1,
AAL05037.1,
AAH05584.1,
BAE30126.1,
BAC29426.1,
BAE40381.1,
BAC37831.1
Ensembl_TRS:
ENSMUST00000175765,
ENSMUST00000176531,
ENSMUST00000177129,
ENSMUST00000176685
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000135224,
ENSMUSP00000135462,
ENSMUSP00000135876,
ENSMUSP00000135435
RefSeq:
NP_001171317.1,
XP_030099888.1,
NP_473437.2,
NP_001171318.1,
NP_001171316.1
|
| Others |
UniRef100:
UniRef100_Q99JY1,
UniRef100_H3BKL1,
UniRef100_Q3UB38
UniRef90:
UniRef90_Q99JY1
UniRef50:
UniRef50_Q99JY1
UniGene:
Mm.23987
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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