| Type | Description |
|---|---|
| Definition | regulating synaptic membrane exocytosis 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:46:00 | Here, the authors identify an essential role for the active zone protein RIM in stimulated somatodendritic dopamine release in the midbrain. In mice in which RIMs are selectively removed from dopamine neurons, action potentials failed to evoke significant somatodendritic release detected via D2 receptor-mediated currents. | 31486769 |
| 2020-01-04 11:41:00 | Conditional deletion of presynaptic proteins RIM1alphabeta (RIM1) from excitatory cortical neurons impairs corticostriatal synaptic transmission in the dorsolateral striatum. RIM1-dependent processes help to promote the refinement of skilled actions, constrain goal-directed behaviors, and support the learning and use of habits. | 30559150 |
| 2019-07-13 10:21:00 | RIM C2B domains are constitutive PIP2-binding molecules that couple mechanisms for synaptic vesical priming. | 29606581 |
| 2019-06-08 10:21:00 | eye-specific segregation in the dLGN and topographic refinement of ipsilateral axons in the SC and the dLGN, are impaired in RIM1/2 conditional knock-out (Rim-cDKO) mice | 28607399 |
| 2018-12-22 10:04:00 | Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking. | 29891949 |
| Type | IDs |
|---|---|
| Synonymous | C030033M19Rik, RIM1, RIM1a, RIM1alpha, Rab3ip1, Rim, Serg1 |
| Gene |
UniProtKB-ID:
RIMS1_MOUSE
UniprotKB:
Q99NE5
UniParc:
UPI000049EEB3,
UPI000049EEB2,
UPI000002807B,
UPI0000EADF4F,
UPI000049EEB1,
UPI000049EEB4,
UPI000049EEB0
EMBL:
AY356534,
AY356537,
AK220335,
AY356535,
AY356536,
AY356538,
AJ310531
KO:
mmu:116837
|
| Nucleutide sequences |
EMBL-CDS:
BAD90402.1,
AAR14800.1,
AAR14798.1,
AAR14801.1,
CAC32041.1,
AAR14797.1,
AAR14799.1
|
| Protein sequencees |
RefSeq:
XP_036010325.1,
XP_036010098.1,
XP_036009936.1,
XP_036010303.1,
NP_444500.2,
XP_036010301.1,
XP_036010264.1,
NP_001012643.2,
XP_036009919.1,
XP_036009994.1,
NP_898839.3,
XP_036010345.1,
XP_036010120.1,
XP_036010304.1,
XP_036010296.1,
XP_036009979.1,
XP_036010199.1,
XP_036010351.1,
XP_036010034.1,
XP_036010141.1,
XP_036010088.1,
XP_036010128.1,
XP_036010136.1,
XP_036010053.1,
XP_036009873.1,
XP_036010331.1,
XP_036010044.1,
XP_036009908.1,
XP_036010190.1,
XP_036010178.1,
XP_036010219.1,
XP_036010207.1,
XP_036009948.1,
XP_036010319.1,
NP_001012642.2,
XP_036010326.1,
NP_001012641.2,
XP_036009856.1,
XP_036010277.1,
XP_036009866.1,
XP_036010340.1,
XP_036010254.1,
XP_036010289.1,
XP_036010307.1,
XP_036010236.1,
XP_036010160.1,
XP_036010149.1,
XP_036009968.1,
XP_036010023.1,
XP_036010071.1
|
| Others |
UniRef100:
UniRef100_Q99NE5
UniRef90:
UniRef90_Q99NE5
UniRef50:
UniRef50_Q86UR5
UniGene:
Mm.60061,
Mm.380549,
Mm.461684
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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