Mapk8 - mitogen-activated protein kinase 8-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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116554 Mapk8

基因描述

Type	Description
Definition	mitogen-activated protein kinase 8

研究结论

Date	Results	Publications
2020-10-24 13:56:00	c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling.	30988348
2020-09-19 16:23:00	Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1beta-induced inflammation in articular chondrocytes via the JNK signaling pathway.	31111559
2020-06-20 10:29:00	FBXW5 reduction alleviates spinal cord injury by blocking microglia activity and down-regulating p38 and JNK.	31060780
2020-04-04 10:45:00	JNK1 expression is elevated in liver cells of rats of different lines receiving excess of easily digested carbohydrates.	31630301
2019-08-24 10:05:00	It was demonstrated in the present study that Syk was markedly activated in the development of Diabetic cardiomyopathy, subsequently promoting NLRP3 inflammasome activation through the phosphorylation of JNK, leading to the cleavage of pro-caspase-1 and maturation of IL-1beta, and finally contributing to diabetic cardiac dysfunction.	30942391

名称对应

Type	IDs
Synonymous	JNK
Gene	UniProtKB-ID: MK08_RAT UniprotKB: P49185 UniParc: UPI000012F17B EMBL: L27129 KO: rno:116554
Nucleutide sequences	EMBL-CDS: AAA42111.1
Protein sequencees	RefSeq: NP_446281.2
Others	UniRef100: UniRef100_P49185 UniRef90: UniRef90_P49185 UniRef50: UniRef50_P49185 UniGene: Rn.4090

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
31111559	Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1Î²-induced inflammation in articular chondrocytes via the JNK signaling pathway. J Cell Biochem Gui-Cheng Gao , Xi-Gao Cheng , Qiang-Qiang Wei , Wei-Cai Chen , Wen-Zhou Huang	2019-10-01	-
31630301	Comparative Analysis of JNK1 Expression in Liver Cells in Rats of Different Lines Receiving Excess of Easily Digested Carbohydrates: Confocal Microscopy. Bull. Exp. Biol. Med. M O Semin , S A Apryatin , I V Gmoshinskii , D B Nikityuk	2019-09-01	-
31060780	FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK. Biochem Biophys Res Commun Pengfei Zhao , Wang Chao , Weiguo Li	2019-06-25	-
30942391	Spleen tyrosine kinaseâinduced JNKâdependent NLRP3 activation is involved in diabetic cardiomyopathy. Int. J. Mol. Med. Shengyu Li , Ruiqing Liu , Meiting Xue , Yingchun Qiao , Yufeng Chen , Guangfeng Long , Xixi Tian , Yahui Hu , Pengfei Zhou , Xiaohui Dong , Zhi Qi , Yujie Cui , Yanna Shen	2019-06-01	-
30988348	c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep C A Escudero , C Cabeza , G Moya-Alvarado , M T Maloney , C M Flores , C Wu , F A Court , W C Mobley , F C Bronfman	2019-04-15	-
29896988	Influence of hypothyroidism on testicular mitochondrial oxidative stress by activating the p38 mitogen-activated protein kinase and c-Jun NH₂-terminal kinase signaling pathways in rats. Hum Exp Toxicol X-R Chang , Y-L Yao , D Wang , H-T Ma , P-H Gou , C-Y Li , J-L Wang	2019-01-01	-
29901107	Autophagy protects bone marrow mesenchymal stem cells from palmitateâinduced apoptosis through the ROSâJNK/p38 MAPK signaling pathways. Mol Med Rep Yongyi Liu , Ning Wang , Shaokun Zhang , Qingwei Liang	2018-08-01	-
29207022	Role of the c-Jun N-terminal kinase signaling pathway in the activation of trypsinogen in rat pancreatic acinar cells. Int. J. Mol. Med. Zhengpeng Yang , Weiguang Yang , Ming Lu , Zhituo Li , Xin Qiao , Bei Sun , Weihui Zhang , Dongbo Xue	2018-02-01	-
29115603	Amelioration of lung ischemiaâreperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemiaâreperfusion injury lung transplantation model. Mol Med Rep Juan Wang , Jing Tan , Yanhong Liu , Linlin Song , Di Li , Xiaoguang Cui	2018-01-01	-
29153991	Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports Ki Beom Bae , Dong Hoon Yu , Kun Yeong Lee , Ke Yao , Joohyun Ryu , Do Young Lim , Tatyana A Zykova , Myoung Ok Kim , Ann M Bode , Zigang Dong	2017-12-12	-

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