| Type | Description |
|---|---|
| Definition | kinase D-interacting substrate 220 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:07:00 | Excitotoxicity induces Kidins220 and GluN1 traffic to the Golgi apparatus before Kidins220 is degraded by the protease calpain. Excitotoxicity also triggers an early activation of Rap1-GTPase followed by its inactivation. Kidins220 excitotoxic endocytosis and subsequent calpain-mediated downregulation governs inactivation of Rap1 that is associated to decreases in ERK activity preceding neuronal death. | 31296845 |
| 2017-09-30 13:50:00 | This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. | 27005418 |
| 2017-08-05 10:45:00 | overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF | 26966186 |
| 2016-04-30 10:09:00 | the existence of novel Kidins220/ARMS splice isoforms with unique properties | 26083449 |
| 2012-11-24 11:01:00 | a novel partner of Kidins220/ARMS | 22609016 |
| Type | IDs |
|---|---|
| Synonymous | ARMS |
| Gene |
UniProtKB-ID:
KDIS_RAT,
A0A0H4T4D0_RAT
UniprotKB:
Q9EQG6,
A0A0H4T4D0
UniParc:
UPI0000049B10,
UPI0001642843
EMBL:
AF313464,
AF239045,
KR081256
KO:
rno:116478
|
| Nucleutide sequences |
EMBL-CDS:
AAG35185.2,
AAG34167.1,
AKP95860.1
|
| Protein sequencees |
RefSeq:
XP_017449470.1,
XP_017449471.1,
XP_006239988.1,
XP_006239991.1,
XP_006239995.1,
XP_006239998.1,
XP_006239986.1,
XP_017449469.1,
XP_006239990.1,
XP_006239999.1,
XP_017449467.1,
XP_006239993.1,
XP_006239989.1,
XP_006239985.1,
XP_006239996.1,
XP_006239994.1,
XP_006239987.1,
XP_017449468.1,
XP_006239997.1,
XP_017449466.1,
NP_446247.2,
XP_017449472.1
|
| Others |
UniRef100:
UniRef100_Q9EQG6
UniRef90:
UniRef90_Q9EQG6
UniRef50:
UniRef50_Q9EQG6
UniGene:
Rn.21470
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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