| Type | Description |
|---|---|
| Definition | DNA topoisomerase I mitochondrial |
| Date | Results | Publications |
|---|---|---|
| 2019-02-23 13:15:00 | Study demonstrated that lack of TOP1MT results in delayed and decreased tumor growth due to impaired mitochondrial translation. The TOP1MT genomic signature profile, based on mouse model for Top1mt-KO liver cancers, is correlated with enhanced survival of hepatocellular carcinoma patients. | 30622257 |
| 2018-06-09 10:35:00 | This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. | 28874393 |
| 2014-08-16 11:23:00 | Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. | 24172750 |
| 2013-09-21 11:02:00 | DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. | 23261817 |
| 2013-09-14 10:46:00 | Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. | 23422507 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TOP1M_HUMAN,
E5KMK7_HUMAN,
B4DYD2_HUMAN
UniprotKB:
Q969P6,
E5KMK7,
B4DYD2
UniParc:
UPI0000D4C3BA,
UPI00017A8209,
UPI000013716D
EMBL:
HQ205014,
HQ205008,
AF349019,
AF349017,
HQ205020,
AC087793,
HQ205006,
HQ205023,
HQ204988,
HQ205009,
AF349025,
AK302372,
AF349024,
HQ205015,
HQ204997,
AF349022,
HQ205000,
AK316380,
HQ205011,
BC071914,
BC052285,
AF349026,
HQ204989,
HQ205001,
HQ204999,
HQ205016,
HQ205007,
AF349023,
AF349027,
BC044646,
HQ204992,
AF349029,
HQ205005,
AF349028,
HQ204998,
AF349018,
AF349021,
AF349030,
HQ205002,
AF349020,
HQ204990,
HQ205018,
HQ205012,
AF349031,
HQ205017
Ensembl:
ENSG00000184428
KO:
hsa:116447
|
| Nucleutide sequences |
EMBL-CDS:
AAL10791.1,
AAH44646.1,
AAH71914.1,
AAH52285.1,
AAL05624.1,
BAH14751.1,
ADP90416.1,
ADP90430.1,
ADP90446.1,
ADP90426.1,
ADP90448.1,
ADP90445.1,
ADP90435.1,
ADP90443.1,
ADP90420.1,
ADP90427.1,
ADP90434.1,
ADP90417.1,
ADP90429.1,
ADP90439.1,
ADP90442.1,
ADP90437.1,
ADP90451.1,
ADP90425.1,
ADP90433.1,
ADP90436.1,
ADP90428.1,
ADP90440.1,
ADP90444.1,
ADP90418.1,
BAG63694.1
Ensembl_TRS:
ENST00000523676,
ENST00000521193,
ENST00000519148,
ENST00000329245
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000428369,
ENSP00000429181,
ENSP00000429169,
ENSP00000328835
RefSeq:
NP_001245376.1,
NP_001245375.1,
XP_005250838.1,
NP_443195.1
|
| Others |
UniRef100:
UniRef100_Q969P6,
UniRef100_E5KMK5
UniRef90:
UniRef90_Q969P6
UniRef50:
UniRef50_Q969P6
UniGene:
Hs.528574
CCDS:
CCDS6400.1,
CCDS59115.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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