| Type | Description |
|---|---|
| Definition | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:17:00 | A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation. | 32845012 |
| 2021-04-13 10:15:00 | Aire Gene Influences the Length of the of mRNAs in Medullary Thymic Epithelial Cells. | 32547551 |
| 2020-07-25 10:28:00 | Aire utilizes its caspase activation recruitment domain (CARD) to form filamentous homo-multimers in vitro, and this assembly mediates foci formation and transcriptional activity. | 32242017 |
| 2020-02-01 11:45:00 | The results showed that Aire deficiency caused increased number of TFH cells, both in vivo and in vitro. Further studies showed that Aire deficiency promoted TFH differentiation through the upregulation of ICOSL and IL-6 in DCs. Thus Aire could suppress the expression of ICOSL and IL-6 to inhibit TFH cell differentiation. | 31023489 |
| 2020-02-01 11:18:00 | CARD domain of AIRE enhances caspase-3 expression through possible direct DNA binding and triggers non-apoptotic downstream signaling in cultured spermatogonial cells. | 31942786 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
AIRE_MOUSE,
Q3ZB71_MOUSE,
B2MVU6_MOUSE,
Q3ZB65_MOUSE
UniprotKB:
Q9Z0E3,
Q3ZB71,
B2MVU6,
Q3ZB65
UniParc:
UPI000002A381,
UPI000002A387,
UPI000002A37E,
UPI000002A383,
UPI000002A380,
UPI000002A384,
UPI000016C8AD,
UPI00000294EA,
UPI000002A385,
UPI000002A382,
UPI000002A37F,
UPI000002A386
EMBL:
AF128773,
AJ007715,
AF128119,
AF079536,
AF128122,
BC103518,
AJ132243,
AF128120,
AF128117,
JF267399,
AF128118,
AF128125,
AF128115,
AF128124,
EU625343,
AF128116,
AF128772,
AF128123,
AF128121,
BC103511,
AJ243821,
AF105002
Ensembl:
ENSMUSG00000000731
KO:
mmu:11634
|
| Nucleutide sequences |
EMBL-CDS:
AAF36464.1,
AAF36482.1,
CAA07620.1,
AAF36467.1,
AAF36461.1,
AAF36470.1,
AAF36465.1,
AAF36462.1,
AAF36463.1,
AAD46421.1,
AAF36466.1,
AAF36481.1,
AAF36468.1,
AAF36460.1,
CAB66141.1,
CAB36909.1,
AAD20444.1,
AAF36469.1,
AAI03512.1,
ACC85597.3,
ADZ48462.1,
AAI03519.1
Ensembl_TRS:
ENSMUST00000128241,
ENSMUST00000140636,
ENSMUST00000155021,
ENSMUST00000148469,
ENSMUST00000105395,
ENSMUST00000130972,
ENSMUST00000145975,
ENSMUST00000105396,
ENSMUST00000156417,
ENSMUST00000019257,
ENSMUST00000154374
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019257,
ENSMUSP00000120150,
ENSMUSP00000122659,
ENSMUSP00000118317,
ENSMUSP00000114904,
ENSMUSP00000121477,
ENSMUSP00000115162,
ENSMUSP00000101035,
ENSMUSP00000117094,
ENSMUSP00000122190,
ENSMUSP00000101034
RefSeq:
NP_001258484.1,
NP_001258487.1,
XP_011241579.1,
NP_001258485.1,
NP_001258478.1,
NP_001258482.1,
NP_001258483.1,
NP_001258479.1,
NP_001258488.1,
NP_001258480.1,
NP_033776.1,
NP_001258486.1,
NP_001258481.1
|
| Others |
UniRef100:
UniRef100_Q3ZB65,
UniRef100_Q9Z0E3,
UniRef100_Q3ZB71
UniRef90:
UniRef90_Q3ZB71,
UniRef90_Q9Z0E3
UniRef50:
UniRef50_Q9Z0E3,
UniRef50_A0A3Q0CKQ0
UniGene:
Mm.35300
CCDS:
CCDS70058.1,
CCDS70055.1,
CCDS70057.1,
CCDS23961.1,
CCDS70054.1,
CCDS70051.1,
CCDS70052.1,
CCDS70056.1,
CCDS70053.1,
CCDS70059.1,
CCDS70060.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Ensembl: {{protein.proteinEnsembl}} |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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