| Type | Description |
|---|---|
| Definition | RAS guanyl releasing protein 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 11:05:00 | The findings indicate the oncogenic role of RasGRP4 in diffuse large B cell lymphoma (DLBCL), suggesting it as a prognostic biomarker and potential therapeutic target in DLBCL. | 31409422 |
| 2015-04-25 11:33:00 | Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation. | 25330932 |
| 2012-12-22 10:39:00 | Identification of defective isoforms of hRasGRP4 transcripts in rheumatoid arthritis(RA) patients raises the possibility that dysregulated expression of hRasGRP4 in developing monocytes plays a pathogenic role in this subset of RA patients. | 21933395 |
| 2012-09-29 11:07:00 | GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. | 22728827 |
| 2010-01-21 00:00:00 | identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function | 11956218 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GRP4_HUMAN
UniprotKB:
Q8TDF6
UniParc:
UPI0001981BBB,
UPI0001981BB8,
UPI0001981BBD,
UPI000015FD13,
UPI0000050F40,
UPI0000164A42,
UPI0001981BBA,
UPI0001981BB9
EMBL:
FJ768679,
AY048121,
AY048120,
FJ768680,
FJ768677,
BC146669,
AY048119,
AF448437,
AC011469,
FJ768678,
AC093076,
FJ768682,
AC005789,
BC150202
Ensembl:
ENSG00000171777
KO:
hsa:115727
|
| Nucleutide sequences |
EMBL-CDS:
ACN82416.1,
ACN82417.1,
AAK85701.1,
ACN82414.1,
AAI50203.1,
AAK85702.1,
AAL87858.1,
AAI46670.1,
ACN82419.1,
AAK85703.1,
ACN82415.1
Ensembl_TRS:
ENST00000614135,
ENST00000587753,
ENST00000293062,
ENST00000426920,
ENST00000589358,
ENST00000622174,
ENST00000615439,
ENST00000433821,
ENST00000586305,
ENST00000587738,
ENST00000454404,
ENST00000589474,
ENST00000617966
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000411878,
ENSP00000465742,
ENSP00000479078,
ENSP00000445966,
ENSP00000293062,
ENSP00000465772,
ENSP00000484345,
ENSP00000466928,
ENSP00000479844,
ENSP00000468483,
ENSP00000479888,
ENSP00000467604,
ENSP00000416463
RefSeq:
NP_001139676.1,
NP_001139674.1,
NP_001139677.1,
NP_001139679.1,
NP_001139678.1,
NP_001139675.1,
NP_733749.1
|
| Others |
UniRef100:
UniRef100_Q8TDF6
UniRef90:
UniRef90_Q8TDF6
UniRef50:
UniRef50_Q8TDF6
UniGene:
Hs.130434
CCDS:
CCDS54262.1,
CCDS46068.1,
CCDS54264.1,
CCDS54263.1,
CCDS59382.1,
CCDS59383.1,
CCDS59384.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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