| Type | Description |
|---|---|
| Definition | Rho guanine nucleotide exchange factor 25 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-26 10:56:00 | p63RhoGEF(619) relocates to the plasma membrane upon activation of Galphaq coupled GPCRs, resembling the well-known activation mechanism of RhoGEFs activated by Galpha12/13. | 27833100 |
| 2016-08-20 10:11:00 | p63RhoGEF can rapidly activate RhoA through endogenous G-protein coupled receptors. | 26435194 |
| 2014-09-27 11:24:00 | assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hypertensive and Bartter's and Gitelman's syndrome patients, a model opposite to hypertension | 24356540 |
| 2014-02-22 12:34:00 | Signaling efficiency of Galphaq through its effectors p63RhoGEF and GEFT depends on their subcellular location. | 23884432 |
| 2013-05-04 11:43:00 | p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. | 23380069 |
| Type | IDs |
|---|---|
| Synonymous | GEFT, p63RhoGEF |
| Gene |
UniProtKB-ID:
ARHGP_HUMAN
UniprotKB:
Q86VW2
UniParc:
UPI000173A6BB,
UPI00003668DB,
UPI000013DE52
EMBL:
BC047559,
BC012860,
AB370196,
CH471054,
BC018536,
AF487514,
AC025165
Ensembl:
ENSG00000240771
KO:
hsa:115557
|
| Nucleutide sequences |
EMBL-CDS:
AAO49463.2,
BAF94999.1,
AAH12860.1,
EAW97037.1,
AAH18536.1,
AAH47559.1
Ensembl_TRS:
ENST00000616622,
ENST00000286494,
ENST00000333972
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000335560,
ENSP00000286494,
ENSP00000484303
RefSeq:
NP_891992.3,
NP_001104740.2,
NP_001334862.2
|
| Others |
UniRef100:
UniRef100_Q86VW2
UniRef90:
UniRef90_Q86VW2
UniRef50:
UniRef50_Q86VW2
UniGene:
Hs.61581
CCDS:
CCDS8947.1,
CCDS44931.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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