| Type | Description |
|---|---|
| Definition | FCH domain only 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 12:40:00 | Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. | 27237791 |
| 2016-04-16 10:08:00 | The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2. | 25303365 |
| 2012-09-15 10:47:00 | FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 is needed for LDLR endocytosis under conditions of low AP2. | 22323290 |
| 2012-06-30 11:50:00 | show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub | 22484487 |
| 2010-01-21 00:00:00 | This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities | 17540576 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
FCHO2_HUMAN
UniprotKB:
Q0JRZ9
UniParc:
UPI0000E8A8C1,
UPI000019971A,
UPI000199421C
EMBL:
AK295141,
AC020893,
BC137070,
AK291782,
AC008972,
AC020942,
AL831971,
BC014311
Ensembl:
ENSG00000157107
KO:
hsa:115548
|
| Nucleutide sequences |
EMBL-CDS:
AAH14311.1,
BAF84471.1,
BAG58162.1,
AAI37071.1
Ensembl_TRS:
ENST00000512348,
ENST00000430046
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000427296,
ENSP00000393776
RefSeq:
XP_016864511.1,
XP_016864508.1,
XP_016864506.1,
XP_016864509.1,
NP_620137.2,
XP_016864512.1,
XP_016864510.1,
NP_001139504.1,
XP_016864507.1,
XP_016864505.1
|
| Others |
UniRef100:
UniRef100_Q0JRZ9
UniRef90:
UniRef90_Q3UQN2
UniRef50:
UniRef50_Q3UQN2
UniGene:
Hs.165762
CCDS:
CCDS47230.1,
CCDS54868.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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