Type | Description |
---|---|
Definition | G protein-coupled receptor 146 |
Date | Results | Publications |
---|---|---|
2021-01-09 13:30:00 | GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis. | 32491159 |
2020-05-30 10:15:00 | these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism. | 31778654 |
2013-09-21 10:43:00 | Knockdown of GPR146 blocked C-peptide-induced cFos expression in KATOIII cells. | 23980258 |
Type | IDs |
---|---|
Synonymous | PGR8 |
Gene |
UniProtKB-ID:
GP146_HUMAN,
B4DTD6_HUMAN,
A4D2Q3_HUMAN
UniprotKB:
Q96CH1,
B4DTD6,
A4D2Q3
UniParc:
UPI0000040BAB,
UPI00017A7F41
EMBL:
AK300166,
AY255535,
CH471144,
AK313171,
BK005420,
BC014241,
CH236965
Ensembl:
ENSG00000164849
KO:
hsa:115330
|
Nucleutide sequences |
EMBL-CDS:
AAH14241.1,
AAO85047.1,
BAG61948.1,
BAG35988.1,
EAL23710.1,
EAW87191.1,
DAA64835.1
Gene_ORFName:
hCG_1747714,
tcag7.991
Ensembl_TRS:
ENST00000444847,
ENST00000397095
|
Protein sequencees |
Ensembl_PRO:
ENSP00000380283,
ENSP00000410743
RefSeq:
NP_001290403.1,
XP_011513418.1,
XP_005249670.2,
NP_612454.1,
XP_006715705.1,
XP_006715706.1,
NP_001290402.1
|
Others |
UniRef100:
UniRef100_B4DTD6,
UniRef100_Q96CH1
UniRef90:
UniRef90_Q96CH1,
UniRef90_B4DTD6
UniRef50:
UniRef50_B4DTD6,
UniRef50_Q96CH1
UniGene:
Hs.585007,
Hs.718624
CCDS:
CCDS5321.1
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
暂无数据
Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
---|---|---|---|
32491159 |
GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis. Acta Biochim Biophys Sin (Shanghai) Lan She , Hailun Yao , Lingzhi He , Yajun Li , Jianping Cao |
2020-08-05 | - |
31778654 |
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell Haojie Yu , Antoine Rimbert , Alice E Palmer , Takafumi Toyohara , Yulei Xia , Fang Xia , Leonardo M R Ferreira , Zhifen Chen , Tao Chen , Natalia Loaiza , Nathaniel Brooks Horwitz , Michael C Kacergis , Liping Zhao , BIOS Consortium , Alexander A Soukas , Jan Albert Kuivenhoven , Sekar Kathiresan , Chad A Cowan |
2019-11-27 | - |
28298427 |
Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Mol Syst Biol Kate Sokolina , Saranya Kittanakom , Jamie Snider , Max Kotlyar , Pascal Maurice , Jorge GandÃa , Abla Benleulmi-Chaachoua , Kenjiro Tadagaki , Atsuro Oishi , Victoria Wong , Ramy H Malty , Viktor Deineko , Hiroyuki Aoki , Shahreen Amin , Zhong Yao , Xavier Morató , David Otasek , Hiroyuki Kobayashi , Javier Menendez , Daniel Auerbach , Stephane Angers , Natasa Pržulj , Michel Bouvier , Mohan Babu , Francisco Ciruela , Ralf Jockers , Igor Jurisica , Igor Stagljar |
2017-03-15 | - |
24097068 |
Discovery and refinement of loci associated with lipid levels. Nat. Genet. Cristen J Willer , Ellen M Schmidt , Sebanti Sengupta , Gina M Peloso , Stefan Gustafsson , Stavroula Kanoni , Andrea Ganna , Jin Chen , Martin L Buchkovich , Samia Mora , Jacques S Beckmann , Jennifer L Bragg-Gresham , Hsing-Yi Chang , AyÅe Demirkan , Heleen M Den Hertog , Ron Do , Louise A Donnelly , Georg B Ehret , Tõnu Esko , Mary F Feitosa , Teresa Ferreira , Krista Fischer , Pierre Fontanillas , Ross M Fraser , Daniel F Freitag , Deepti Gurdasani , Kauko Heikkilä , Elina Hyppönen , Aaron Isaacs , Anne U Jackson , à sa Johansson , Toby Johnson , Marika Kaakinen , Johannes Kettunen , Marcus E Kleber , Xiaohui Li , Jian'an Luan , Leo-Pekka Lyytikäinen , Patrik K E Magnusson , Massimo Mangino , Evelin Mihailov , May E Montasser , Martina Müller-Nurasyid , Ilja M Nolte , Jeffrey R O'Connell , Cameron D Palmer , Markus Perola , Ann-Kristin Petersen , Serena Sanna , Richa Saxena , Susan K Service , Sonia Shah , Dmitry Shungin , Carlo Sidore , Ci Song , Rona J Strawbridge , Ida Surakka , Toshiko Tanaka , Tanya M Teslovich , Gudmar Thorleifsson , Evita G Van den Herik , Benjamin F Voight , Kelly A Volcik , Lindsay L Waite , Andrew Wong , Ying Wu , Weihua Zhang , Devin Absher , Gershim Asiki , Inês Barroso , Latonya F Been , Jennifer L Bolton , Lori L Bonnycastle , Paolo Brambilla , Mary S Burnett , Giancarlo Cesana , Maria Dimitriou , Alex S F Doney , Angela Döring , Paul Elliott , Stephen E Epstein , Gudmundur Ingi Eyjolfsson , Bruna Gigante , Mark O Goodarzi , Harald Grallert , Martha L Gravito , Christopher J Groves , Göran Hallmans , Anna-Liisa Hartikainen , Caroline Hayward , Dena Hernandez , Andrew A Hicks , Hilma Holm , Yi-Jen Hung , Thomas Illig , Michelle R Jones , Pontiano Kaleebu , John J P Kastelein , Kay-Tee Khaw , Eric Kim , Norman Klopp , Pirjo Komulainen , Meena Kumari , Claudia Langenberg , Terho Lehtimäki , Shih-Yi Lin , Jaana Lindström , Ruth J F Loos , François Mach , Wendy L McArdle , Christa Meisinger , Braxton D Mitchell , Gabrielle Müller , Ramaiah Nagaraja , Narisu Narisu , Tuomo V M Nieminen , Rebecca N Nsubuga , Isleifur Olafsson , Ken K Ong , Aarno Palotie , Theodore Papamarkou , Cristina Pomilla , Anneli Pouta , Daniel J Rader , Muredach P Reilly , Paul M Ridker , Fernando Rivadeneira , Igor Rudan , Aimo Ruokonen , Nilesh Samani , Hubert Scharnagl , Janet Seeley , Kaisa Silander , Alena StanÄáková , Kathleen Stirrups , Amy J Swift , Laurence Tiret , Andre G Uitterlinden , L Joost van Pelt , Sailaja Vedantam , Nicholas Wainwright , Cisca Wijmenga , Sarah H Wild , Gonneke Willemsen , Tom Wilsgaard , James F Wilson , Elizabeth H Young , Jing Hua Zhao , Linda S Adair , Dominique Arveiler , Themistocles L Assimes , Stefania Bandinelli , Franklyn Bennett , Murielle Bochud , Bernhard O Boehm , Dorret I Boomsma , Ingrid B Borecki , Stefan R Bornstein , Pascal Bovet , Michel Burnier , Harry Campbell , Aravinda Chakravarti , John C Chambers , Yii-Der Ida Chen , Francis S Collins , Richard S Cooper , John Danesh , George Dedoussis , Ulf de Faire , Alan B Feranil , Jean Ferrières , Luigi Ferrucci , Nelson B Freimer , Christian Gieger , Leif C Groop , Vilmundur Gudnason , Ulf Gyllensten , Anders Hamsten , Tamara B Harris , Aroon Hingorani , Joel N Hirschhorn , Albert Hofman , G Kees Hovingh , Chao Agnes Hsiung , Steve E Humphries , Steven C Hunt , Kristian Hveem , Carlos Iribarren , Marjo-Riitta Järvelin , Antti Jula , Mika Kähönen , Jaakko Kaprio , Antero Kesäniemi , Mika Kivimaki , Jaspal S Kooner , Peter J Koudstaal , Ronald M Krauss , Diana Kuh , Johanna Kuusisto , Kirsten O Kyvik , Markku Laakso , Timo A Lakka , Lars Lind , Cecilia M Lindgren , Nicholas G Martin , Winfried März , Mark I McCarthy , Colin A McKenzie , Pierre Meneton , Andres Metspalu , Leena Moilanen , Andrew D Morris , Patricia B Munroe , Inger Njølstad , Nancy L Pedersen , Chris Power , Peter P Pramstaller , Jackie F Price , Bruce M Psaty , Thomas Quertermous , Rainer Rauramaa , Danish Saleheen , Veikko Salomaa , Dharambir K Sanghera , Jouko Saramies , Peter E H Schwarz , Wayne H-H Sheu , Alan R Shuldiner , Agneta Siegbahn , Tim D Spector , Kari Stefansson , David P Strachan , Bamidele O Tayo , Elena Tremoli , Jaakko Tuomilehto , Matti Uusitupa , Cornelia M van Duijn , Peter Vollenweider , Lars Wallentin , Nicholas J Wareham , John B Whitfield , Bruce H R Wolffenbuttel , Jose M Ordovas , Eric Boerwinkle , Colin N A Palmer , Unnur Thorsteinsdottir , Daniel I Chasman , Jerome I Rotter , Paul W Franks , Samuli Ripatti , L Adrienne Cupples , Manjinder S Sandhu , Stephen S Rich , Michael Boehnke , Panos Deloukas , Sekar Kathiresan , Karen L Mohlke , Erik Ingelsson , Gonçalo R Abecasis , Global Lipids Genetics Consortium |
2013-11-01 | - |
23759446 |
Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol Gina L C Yosten , Grant R Kolar , Lauren J Redlinger , Willis K Samson |
2013-01-01 | - |
23980258 |
Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol Gina L C Yosten , Grant R Kolar , Lauren J Redlinger , Willis K Samson |
2013-01-01 | - |
16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
15777626 |
Biochim. Biophys. Acta David E I Gloriam , Helgi B Schiöth , Robert Fredriksson |
2005-04-15 |
Gpr162,
Gpr139,
Gpr165,
Mrfap1,
gpr146,
gpr139,
GPR146,
GPR139,
GPR162,
GPR150,
GPR148,
NPSR1,
GPR153,
GPR152,
GPR165P
|
15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
12690205 |
Human chromosome 7: DNA sequence and biology. Science Stephen W Scherer , Joseph Cheung , Jeffrey R MacDonald , Lucy R Osborne , Kazuhiko Nakabayashi , Jo-Anne Herbrick , Andrew R Carson , Layla Parker-Katiraee , Jennifer Skaug , Razi Khaja , Junjun Zhang , Alexander K Hudek , Martin Li , May Haddad , Gavin E Duggan , Bridget A Fernandez , Emiko Kanematsu , Simone Gentles , Constantine C Christopoulos , Sanaa Choufani , Dorota Kwasnicka , Xiangqun H Zheng , Zhongwu Lai , Deborah Nusskern , Qing Zhang , Zhiping Gu , Fu Lu , Susan Zeesman , Malgorzata J Nowaczyk , Ikuko Teshima , David Chitayat , Cheryl Shuman , Rosanna Weksberg , Elaine H Zackai , Theresa A Grebe , Sarah R Cox , Susan J Kirkpatrick , Nazneen Rahman , Jan M Friedman , Henry H Q Heng , Pier Giuseppe Pelicci , Francesco Lo-Coco , Elena Belloni , Lisa G Shaffer , Barbara Pober , Cynthia C Morton , James F Gusella , Gail A P Bruns , Bruce R Korf , Bradley J Quade , Azra H Ligon , Heather Ferguson , Anne W Higgins , Natalia T Leach , Steven R Herrick , Emmanuelle Lemyre , Chantal G Farra , Hyung-Goo Kim , Anne M Summers , Karen W Gripp , Wendy Roberts , Peter Szatmari , Elizabeth J T Winsor , Karl-Heinz Grzeschik , Ahmed Teebi , Berge A Minassian , Juha Kere , Lluis Armengol , Miguel Angel Pujana , Xavier Estivill , Michael D Wilson , Ben F Koop , Sabrina Tosi , Gudrun E Moore , Andrew P Boright , Eitan Zlotorynski , Batsheva Kerem , Peter M Kroisel , Erwin Petek , David G Oscier , Sarah J Mould , Hartmut Döhner , Konstanze Döhner , Johanna M Rommens , John B Vincent , J Craig Venter , Peter W Li , Richard J Mural , Mark D Adams , Lap-Chee Tsui |
2003-05-02 |
BET1P1,
LOC100129603,
TUBB3P2,
C7orf72,
LOC100131859,
LOC100286906,
HSPA8P8,
LOC100287825,
DNAJB6,
LINC01006,
LOC100506557,
TMEM178B,
ABCF2,
ARPC1B,
ARL4A,
NAMPT,
AKAP9,
AASS,
LOC101927181,
CDK5,
CDK6,
POP7,
RAMP3,
LOC102724434,
BET1,
IKZF1,
SEMA3A,
NOD1,
GPNMB,
SEMA3C,
AGR2,
ARPC1A,
IGF2BP3,
YKT6,
ADCY1,
CFTR,
FGL2,
CPSF4,
FASTK,
COPS6,
KDELR2,
DUS4L,
NUPL2,
HIBADH,
ZNF277,
CHN2,
TP53TG1,
CHRM2,
GLCCI1,
FKBP9,
CBX3,
ZBED6CL,
TSGA13,
GPR146,
MALSU1,
AGAP3,
ADCYAP1R1,
CLK2P1,
C7orf13,
OR9A4,
CPA1,
C7orf34,
TMEM139,
OR2F2,
SSU72P8,
PRSS37,
KLF14,
SSMEM1,
MTPN,
LRGUK,
ASB10,
PRSS58,
MPLKIP,
ASZ1,
CRHR2,
RUNDC3B,
LINC00689,
KCTD7,
C7orf66,
GIMAP8,
CRYGN,
ZNF425,
CYP3A7,
AMZ1,
RBM33,
AGR3,
CYP3A4,
CYP3A5,
CYP51A1,
DGKB,
DDC,
AEBP1,
GALNTL5,
RNF133,
THAP5,
CCDC71L,
GIMAP7,
BHLHA15,
BMPER
|
排名 | 科研单位 | 文献 |
---|---|---|
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{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
排名 | 研究人员 | 文献 |
---|---|---|
{{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员