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11519 Add2

11519

Add2

adducin 2 (beta)

protein-coding

Mus musculus

基因描述

Type Description
Definition adducin 2 (beta)

研究结论

Date Results Publications
2018-02-24 10:35:00 Study shows that a single injection of 3 pharmacologically distinct psychoactive drugs can modify spines in the nucleus accumbens within a day. beta-adducin is necessary for these effects. Study suggests that fine regulation of phosphorylation is a major factor in mediating common effects on beta-adducin of various drugs with distinct or even opposite modes of action. 27480796
2017-11-26 00:38:00 Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction. 29032200
2016-05-14 12:24:00 Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system. 26639316
2015-08-15 10:09:00 Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway. 25305142
2014-01-18 12:01:00 study identified novel long-distance upstream non-canonical polyadenylation-regulatory elements that enhance or silence 3'end processing of the Add2 PAS4 23411391

名称对应

Type IDs
Synonymous 2900072M03Rik, add97
Gene
UniProtKB-ID: ADDB_MOUSE, Q8C0Y2_MOUSE
UniprotKB: Q9QYB8, Q8C0Y2
UniParc: UPI000000BACD, UPI00000EA254, UPI000002336F, UPI0000023370
EMBL: AF100422, BC053032, AF100423, AK014496, AF189770, AK028425, BC046783, AK029488, AF189769, AK156954
Ensembl: ENSMUSG00000030000
KO: mmu:11519
Nucleutide sequences
EMBL-CDS: AAH46783.1, AAF24973.1, AAF29502.1, BAE33913.1, AAF29503.1, AAH53032.1, AAF24972.1, BAC25943.1, BAB29395.1, BAC26472.1
Ensembl_TRS: ENSMUST00000205034, ENSMUST00000203279, ENSMUST00000203196, ENSMUST00000203786, ENSMUST00000203366, ENSMUST00000203724, ENSMUST00000032069, ENSMUST00000204059
Protein sequencees
Ensembl_PRO: ENSMUSP00000144694, ENSMUSP00000145452, ENSMUSP00000032069, ENSMUSP00000145160, ENSMUSP00000145296, ENSMUSP00000145034, ENSMUSP00000145104, ENSMUSP00000144849
RefSeq: NP_038486.2, NP_001258787.1, NP_001258786.1, NP_001258788.1, NP_001258790.1, NP_001258789.1
Others
UniRef100: UniRef100_Q9QYB8, UniRef100_Q8C0Y2
UniRef90: UniRef90_Q9QYB8
UniRef50: UniRef50_P35612
UniGene: Mm.104155, Mm.489430
CCDS: CCDS85085.1, CCDS20308.1

全选

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