| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase mitochondrial 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-06 11:10:00 | SRSF1 regulates lung cancer cell radioresistance through modulating PTPMT1 splicing. Reduced SRSF1 favors the production of short isoforms of PTPMT1 upon ionizing radiation, which in turn promotes phosphorylation of AMPK, thereby inducing DNA double-strand break to sensitize cancer cells to irradiation. | 30429088 |
| 2016-11-12 10:43:00 | A key role for HIF-2alpha-induced Ptpmt1 up-regulation in proliferation, survival and glucose metabolism of erythroleukemia cells. | 26898802 |
| 2015-01-24 10:06:00 | our data support a model in which MK-STYX controls apoptosis by negatively regulating PTPMT1. | 24709986 |
| 2013-07-20 11:25:00 | Our data suggest that inhibition of PTPMT1 causes a metabolic crisis in cancer cells that induces cell death, and may be a mechanism by which cancer cells can be sensitized to currently available therapies. | 23326511 |
| Type | IDs |
|---|---|
| Synonymous | DUSP23, MOSP, PLIP, PNAS-129 |
| Gene |
UniProtKB-ID:
PTPM1_HUMAN
UniprotKB:
Q8WUK0
UniParc:
UPI00001B4EBF,
UPI000153CE47,
UPI00000472C6
EMBL:
BC020242,
AY333987,
BC014048,
AC090559,
BC073798,
AC104942,
AF277187
Ensembl:
ENSG00000110536,
ENSG00000285206
KO:
hsa:114971
|
| Nucleutide sequences |
EMBL-CDS:
AAH20242.1,
AAP94732.1,
AAH14048.1,
AAK07545.1
Gene_ORFName:
PNAS-129
Ensembl_TRS:
ENST00000646905,
ENST00000647378,
ENST00000326674,
ENST00000326656,
ENST00000426530,
ENST00000643547
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000325958,
ENSP00000494387,
ENSP00000410272,
ENSP00000495288,
ENSP00000496417,
ENSP00000325882
RefSeq:
NP_001137456.1,
NP_783859.1
|
| Others |
UniRef100:
UniRef100_Q8WUK0
UniRef90:
UniRef90_Q8WUK0
UniRef50:
UniRef50_Q8WUK0
UniGene:
Hs.656205,
Hs.742231
CCDS:
CCDS44593.1,
CCDS41643.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员