| Type | Description |
|---|---|
| Definition | oxysterol binding protein like 8 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:49:00 | ORP8 induces apoptosis by releasing cytochrome c from mitochondria in nonsmall cell lung cancer. | 32323800 |
| 2019-05-18 11:00:00 | ORP5/8 recruitment to the plasma membrane occurs through interactions with the N-terminal Pleckstrin homology domains and adjacent basic residues of ORP5/8 with both phosphatidylinositol 4-phosphate and Phosphatidylinositol 4,5-bisphosphate. | 29472386 |
| 2018-12-29 10:19:00 | ORP5/8 regulate Ca(2+) signaling at specific membrane contact sites foci. | 29748134 |
| 2018-03-24 11:00:00 | Examination of a series of deletion constructs demonstrated that both the N-terminal polybasic region and the PH domain are required for proper targeting of the short splice variant ORP8S to the PM-ER contact site in Chinese hamster ovary cells. | 29409900 |
| 2018-01-13 12:57:00 | ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM. | 28970484 |
| Type | IDs |
|---|---|
| Synonymous | MST120, MSTP120, ORP8, OSBP10 |
| Gene |
UniProtKB-ID:
OSBL8_HUMAN,
Q5HYM3_HUMAN,
A0A024RBB8_HUMAN
UniprotKB:
Q9BZF1,
Q5HYM3,
A0A024RBB8
UniParc:
UPI00002264B2,
UPI00004C4117,
UPI000006ECD1,
UPI0000130E99
EMBL:
BC093834,
CR749542,
BC111728,
BC101529,
AF323730,
AK289997,
AC122687,
BX647211,
AC124943,
CH471054,
AF392452,
AB040884,
AC117491
Ensembl:
ENSG00000091039
KO:
hsa:114882
|
| Nucleutide sequences |
EMBL-CDS:
AAL40665.1,
BAA95975.3,
AAI11729.1,
AAI01530.1,
AAG53411.1,
AAH93834.1,
CAH18345.1,
BAF82686.1,
CAI46050.1,
EAW97325.1,
EAW97326.1
Gene_ORFName:
hCG_27425
Ensembl_TRS:
ENST00000611266,
ENST00000261183,
ENST00000393249,
ENST00000393250
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478240,
ENSP00000261183,
ENSP00000376940,
ENSP00000376939
RefSeq:
XP_016874258.1,
XP_024304597.1,
NP_001003712.1,
NP_001306581.1,
NP_065892.1,
XP_011536157.1,
NP_001306582.1,
NP_001306584.1,
XP_005268678.1,
XP_016874257.1,
XP_011536159.1,
XP_011536158.1,
XP_006719287.1
|
| Others |
UniRef100:
UniRef100_Q9BZF1,
UniRef100_Q5HYM3
UniRef90:
UniRef90_Q9BZF1
UniRef50:
UniRef50_Q9BZF1
UniGene:
Hs.430849
CCDS:
CCDS31862.1,
CCDS41814.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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