| Type | Description |
|---|---|
| Definition | oxysterol binding protein like 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:11:00 | ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites? | 32570981 |
| 2019-05-18 11:00:00 | ORP5/8 recruitment to the plasma membrane occurs through interactions with the N-terminal Pleckstrin homology domains and adjacent basic residues of ORP5/8 with both phosphatidylinositol 4-phosphate and Phosphatidylinositol 4,5-bisphosphate. | 29472386 |
| 2019-01-12 10:47:00 | Data suggest that ORP5/OSBPL5 promotes cell proliferation, cell motility, and invasiveness of neoplasm cells; this effect of ORP5/OSBPL5 depends on functional OSBP-related domain (ORD). ORP5/OSBPL5 is needed for activation of mTORC1 signaling and for transport of mTOR to lysosomes. (mTORC1 = mechanistic target of rapamycin complex-1; mTOR = mechanistic target of rapamycin) | 29358326 |
| 2018-12-29 10:19:00 | ORP5/8 regulate Ca(2+) signaling at specific membrane contact sites foci. | 29748134 |
| 2018-01-13 12:57:00 | ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM. | 28970484 |
| Type | IDs |
|---|---|
| Synonymous | OBPH1, ORP5 |
| Gene |
UniProtKB-ID:
OSBL5_HUMAN,
A8KAD5_HUMAN
UniprotKB:
Q9H0X9,
A8KAD5
UniParc:
UPI000000D722,
UPI000015FE61,
UPI00015DAAA0,
UPI00017A7EBA
EMBL:
AK056510,
AK293000,
AC108448,
BC032646,
KF455310,
AK301003,
AF331964,
BC039579,
KC877382,
AL136918,
AB074006,
KF455307,
AB040967,
AF392453,
CH471158,
AF410430
Ensembl:
ENSG00000021762
KO:
hsa:114879
|
| Nucleutide sequences |
EMBL-CDS:
EAX02542.1,
AAH39579.1,
AAL40666.1,
BAB85686.1,
AAG53417.1,
EAX02543.1,
BAG51735.1,
BAA96058.1,
AAK98617.1,
BAG62622.1,
AAH32646.2,
CAB66852.1,
BAF85689.1
Ensembl_TRS:
ENST00000348039,
ENST00000263650,
ENST00000389989,
ENST00000525498
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263650,
ENSP00000302872,
ENSP00000433342,
ENSP00000374639
RefSeq:
NP_001137535.1,
NP_663613.1,
XP_016872652.1,
XP_011518175.1,
NP_065947.1,
XP_016872653.1
|
| Others |
UniRef100:
UniRef100_A8KAD5,
UniRef100_Q9H0X9
UniRef90:
UniRef90_Q9H0X9,
UniRef90_Q9H0X9-2
UniRef50:
UniRef50_Q9H0X9-2,
UniRef50_Q9H0X9
UniGene:
Hs.436166
CCDS:
CCDS31343.1,
CCDS31344.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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