| Type | Description |
|---|---|
| Definition | activin A receptor, type 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:01:00 | ALK4/5-dependent TGF-beta signaling contributes to the crosstalk between neurons and microglia following axonal lesion. | 31053759 |
| 2019-11-23 12:55:00 | Results demonstrate that ALK 4 haplodeficiency ameliorates atrial remodeling and vulnerability to atrial fibrillation in a pressure-overload model through inactivation of the Smad2/3 pathway. | 30369314 |
| 2018-04-07 12:01:00 | Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation | 28639003 |
| 2017-09-16 12:56:00 | Our results demonstrate that ALK4 haploinsufficiency ameliorates cardiac fibrosis and dysfunction in a mouse pressure-overload model associated with inhibition of cardiac fibroblast activation and cardiomyocyte apoptosis through the suppression of Smad2/3 activity. | 27379535 |
| 2017-06-03 10:58:00 | ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated | 28214509 |
| Type | IDs |
|---|---|
| Synonymous | 6820432J04, ALK-4, ActR-IB, ActRIB, Acvrlk4, Alk4, SKR2 |
| Gene |
UniProtKB-ID:
ACV1B_MOUSE,
Q3TZF1_MOUSE
UniprotKB:
Q61271,
Q3TZF1
UniParc:
UPI0000020AB0
EMBL:
Z31663,
AK157910,
BC145775,
BC145777
Ensembl:
ENSMUSG00000000532
KO:
mmu:11479
|
| Nucleutide sequences |
EMBL-CDS:
CAA83483.1,
AAI45776.1,
BAE34258.1,
AAI45778.1
Ensembl_TRS:
ENSMUST00000000544
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000000544
RefSeq:
NP_031421.1
|
| Others |
UniRef100:
UniRef100_Q61271
UniRef90:
UniRef90_P36896
UniRef50:
UniRef50_P36897
UniGene:
Mm.308467
CCDS:
CCDS27846.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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