| Type | Description |
|---|---|
| Definition | lemur tyrosine kinase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 12:14:00 | Our findings support a model in which the MIR2052HG regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via the axis. These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer. | 30944027 |
| 2019-03-09 12:37:00 | targeting of LMTK3 with siRNA delayed KIT-dependent GIST growth in a xenograft model. Our data suggest the potential of LMTK3 as a target for treatment of patients with KIT-mutant cancer, particularly after failure of KIT TKIs. | 30242244 |
| 2019-03-09 10:10:00 | LMTK3 expression and its role in the drug resistance in breast cancer. | 29540829 |
| 2018-11-10 10:42:00 | Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart. | 28294115 |
| 2017-11-18 13:26:00 | LMTK-3 increased phosphorylated p38 and JNK, but decreased phosphorylated ERK1/2 and AKT. Overexpression of LMTKs may contribute to biologic behavior changes of PCa, especially cell apoptosis. | 28848113 |
| Type | IDs |
|---|---|
| Synonymous | LMR3, PPP1R101, TYKLM3 |
| Gene |
UniProtKB-ID:
A0A3B3ISL5_HUMAN,
A0A0A0MQW5_HUMAN
UniprotKB:
A0A3B3ISL5,
A0A0A0MQW5
UniParc:
UPI00001D8182,
UPI0003E63E60
EMBL:
AC008403
Ensembl:
ENSG00000142235
KO:
hsa:114783
|
| Nucleutide sequences |
Ensembl_TRS:
ENST00000650440,
ENST00000270238
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000497480,
ENSP00000270238
RefSeq:
XP_011524714.1,
NP_001073903.2,
NP_001375414.1,
XP_011524713.1
|
| Others |
UniRef100:
UniRef100_Q96Q04,
UniRef100_A0A3B3ISL5
UniRef90:
UniRef90_Q96Q04
UniRef50:
UniRef50_Q96Q04
UniGene:
Hs.207426
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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