| Type | Description |
|---|---|
| Definition | sprouty-related, EVH1 domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. | 33020583 |
| 2020-07-25 12:43:00 | Using established mice lines deficient for either or both Spred 1 and Spred 2, we demonstrate their role in regulating lens development by negatively regulating ERK1/2 activity. | 31923414 |
| 2020-06-27 11:09:00 | SPRED2 deficiency impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias. | 30771306 |
| 2019-12-21 10:45:00 | we showed that Spred2-deficiency promotes obesity, adipose tissue inflammation, and insulin resistance, possibly via enhanced adipose tissue inflammation caused by enhanced macrophage activation. | 30723473 |
| 2019-06-29 11:18:00 | Spred2-deficiency protects mice from polymicrobial sepsis via increased activation of the ERK/MAPK pathway and subsequent increase in innate immune responses. | 28993690 |
| Type | IDs |
|---|---|
| Synonymous | C79158 |
| Gene |
UniProtKB-ID:
SPRE2_MOUSE
UniprotKB:
Q924S7
UniParc:
UPI0000029038
EMBL:
AB063496,
BC066013,
AK036430
Ensembl:
ENSMUSG00000045671
KO:
mmu:114716
|
| Nucleutide sequences |
EMBL-CDS:
BAB62849.1,
AAH66013.1,
BAC29425.1
Ensembl_TRS:
ENSMUST00000093298
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000090987
RefSeq:
NP_277058.1,
XP_006514520.1,
XP_006514519.1,
XP_006514521.1,
XP_036012129.1
|
| Others |
UniRef100:
UniRef100_Q924S7
UniRef90:
UniRef90_Q924S7
UniRef50:
UniRef50_Q924S7
UniGene:
Mm.266627
CCDS:
CCDS24454.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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