Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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114711 Gne

基因描述

Type	Description
Definition	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

研究结论

Date	Results	Publications
2012-03-24 11:47:00	M712T mutation of GNE gene does not affect GNE oligomerization but affects the solubility and posttranslational modification of the GNE protein.	21873062
2010-01-21 00:00:00	analysis of ligand binding to UDP-GlcNAc 2-epimerase by NMR	15498764
2010-01-21 00:00:00	Data show that overexpression of GNE induces neurite outgrowth in PC12 cells, but does not lead to an increased biosynthesis of sialic acid.	18628673
2010-01-21 00:00:00	structures required for dimerization are localized within the kinase domain, and a potential trimerization site is possibly located in a region between the two domains	15330759
2010-01-21 00:00:00	analysis of oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods	17448495

名称对应

Type	IDs
Synonymous	Uae1
Gene	UniProtKB-ID: GLCNE_RAT, A0A0G2K7T2_RAT UniprotKB: O35826, A0A0G2K7T2 UniParc: UPI0000DBFD0C, UPI00000E7629 EMBL: Y07744, BC062011, CH473962, AC127935 Ensembl: ENSRNOG00000014365 KO: rno:114711
Nucleutide sequences	EMBL-CDS: AAH62011.1, CAA69024.1, EDL98788.1 Gene_ORFName: rCG_55118 Ensembl_TRS: ENSRNOT00000019532, ENSRNOT00000090490
Protein sequencees	Ensembl_PRO: ENSRNOP00000019532, ENSRNOP00000074334 RefSeq: NP_446217.1, XP_006238068.1, XP_017448606.1, XP_006238070.1, XP_006238071.1
Others	UniRef100: UniRef100_O35826 UniRef90: UniRef90_Q9Y223 UniRef50: UniRef50_Q9Y223 UniGene: Rn.18753

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
24625528	Interactome analysis of AMP-activated protein kinase (AMPK)-Î±1 and -Î²1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Sci Rep Sungyoon Moon , Dohyun Han , Yikwon Kim , Jonghwa Jin , Won-Kyung Ho , Youngsoo Kim	2014-01-01	-
22871113	Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. J. Proteome Res. Chan Hyun Na , Drew R Jones , Yanling Yang , Xusheng Wang , Yanji Xu , Junmin Peng	2012-09-07	Rab1b, Tmem59, Msh6, LOC100360426, Sncb, Csnk1a1, Magi2, Cxcl2, Dnm1l, Gng3, Hcn2, Clasp2, Ubqln1, Gne, Stx1a, Txn1, Sec14l2, Gripap1, Mprip, Slc6a9, Ralb, Ap2m1, Nrxn2, Slc17a7, Vcp, Cap2, Dlgap2, Lmnb1, Trim28, Epb41l3, Ube2n, Gp1bb, Nup155, Bin1, Rpl6, H3f3b, Nlgn2, Prdx1, Psmc4, Psmc1, Epn1, Ppp2r1a, Hnrnpk, Lrrc7, Txnip, Uba3, Sv2b, Tpm3, Sv2a, Atp6v1b2, Rps20, Slc8a2, Rps3, Faf1, Ap2b1, Dnm1, Cacng8, Cdk5, Txnl1, Ggt7, Prkcd, Palm, Atp2c1, Dynlrb1, Kcnh7, Xpnpep1, Atxn10, Kcnq2, Cry2, Rab3c, Ndrg2, Camk2g, Pabpc1, Eef1a1, Slc12a5, Acsbg1, Tmem176b, Nme1, Tecr, Syngap1, Hip1, Gpm6b, Ehd4, Rasgrf1, Plpp3, Stip1, Caly, Aldoa, Aldoc, Atp1a1, Atp1a2, Atp1a3, Atp2b2, Cacna1c, Calm1, Camk2d, Ckb, Eno1, Gapdh
21873062	Biochemical characterization of the M712T-mutation of the UDP-N-acetylglucosamine 2-epimerase/N-acetyl-mannosaminekinase in hereditary inclusion body myopathy. Neuromuscul. Disord. Wenke Weidemann , Anika Reinhardt , Annett Thate , RÃ¼diger Horstkorte	2011-12-01	Gne
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
18628673	The key enzyme of sialic acid biosynthesis (GNE) promotes neurite outgrowth of PC12 cells. Neuroreport Maria Kontou , Wenke Weidemann , Christian Bauer , Werner Reutter , RÃ¼diger Horstkorte	2008-08-06	Gne
17448495	Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods. J. Mol. Biol. Darius Ghaderi , Holger M Strauss , Stefan Reinke , Sebahattin Cirak , Werner Reutter , Lothar Lucka , Stephan Hinderlich	2007-06-08	Gne, Nagk
17118363	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. FEBS Lett. Wenke Weidemann , Ulrich Stelzl , Ulrike Lisewski , Kaya Bork , Erich E Wanker , Stephan Hinderlich , RÃ¼diger Horstkorte	2006-12-11	Gne, Crmp1, GNE, CRMP1, RIF1, KIAA1549, ZBTB16
15498764	Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: I. Investigation of the UDP-GlcNAc 2-epimerase functionality. J Biol Chem Astrid Blume , Andrew J Benie , Florian Stolz , Richard R Schmidt , Werner Reutter , Stephan Hinderlich , Thomas Peters	2005-12-31	-
15330759	Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Biochem. J. Astrid Blume , Wenke Weidemann , Ulrich Stelzl , Erich E Wanker , Lothar Lucka , Peter Donner , Werner Reutter , RÃ¼diger Horstkorte , Stephan Hinderlich	2004-12-15	Gne
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team	2004-10-01	Ldlrap1, Dnajc3, Rnaset2a, Btnl1, Isg15, Cyp3a41b, Ly6c2, Ccl21b, Eif3j2, Mup18, Lrrc19, Rcc1, 1700047I17Rik2, Pcsk9, Adat3, Tdrd7, Sco2, Gpr153, Pafah2, Gm44504, H6pd, Adprhl2, Gpn2, Rusc2, Stx12, Ppp1r8, Smpdl3b, Fam46b, Bsdc1, Slc44a1, Zfand2a, Rubcn, Kifc1, Pifo, C030017K20Rik, Cbarp, Rpl5, Micalcl, Atg14, Lrrc8c, Noc4l, Nsun5, Psph, Trrap, Mapre3, Ube3c, Tbc1d14, Hscb, Tyw1, Emilin1, Rab28, Pot1a, Parp11, Tada3, Tra2a, Brk1, Fbxl14, Phrf1, Plekha1, Gm21975, Ric8a, Mob2, Prkd2, Ccp110, Vrk3, Grwd1, Nlrp6, Trim68, Psip1, Spred3, Faap24, Ints4, Rrp8, Unc45a, Igflr1, Sf3b3, D8Ertd738e, Usb1, Champ1, Smim19, Exoc8, Gadd45gip1, Phkb, Dohh, Fam192a, Enkd1, Taf5l, Zdhhc7, Snapc2, Ak6, Gpat4, Dcun1d2, Ankrd10, Cog4, Hinfp, Lars2, Xylb, Imp3, Cmtm7

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