| Type | Description |
|---|---|
| Definition | cholinergic receptor nicotinic beta 3 subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 11:51:00 | This study is the first showing that CHRNB3/A6 are highly associated with nicotine dependence in a large Chinese Han sample. | 28851948 |
| 2017-11-18 10:13:00 | To gain a better understanding of the pathological processes underlying ND and ND-related behaviors and to promote the development of effective smoking cessation therapies, we here present the most recent studies concerning the genetic effects of the CHRNB3-CHRNA6 gene cluster in ND. | 27327258 |
| 2017-06-03 10:53:00 | This study shows that unorthodox acetylcholine binding sites can form at the alpha5/alpha4 and beta3/alpha4 interfaces in (alpha4beta2)2alpha5 and (alpha4beta2)2beta3 nicotinic acetylcholine receptors (nAChRs) and at the alpha4/alpha5 in (beta2alpha4)2alpha5 nAChRs. | 27645992 |
| 2017-05-13 14:25:00 | More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls. | 27085880 |
| 2016-09-03 11:20:00 | Data provide evidence that the protective genetic variant at rs6474413 identified in human genetic studies reduces gene expression and that decreased beta3 gene expression in mice reduces nicotine intake | 26318101 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ACHB3_HUMAN
UniprotKB:
Q05901
UniParc:
UPI0000125272
EMBL:
BC069788,
AF140764,
X67513,
AF140763,
AF140765,
AF140761,
AF140760,
BC069703,
BC069681,
U62438,
AF140762,
Y08417
Ensembl:
ENSG00000147432
KO:
hsa:1142
|
| Nucleutide sequences |
EMBL-CDS:
CAA69694.1,
AAH69788.1,
AAH69703.1,
AAD33063.1,
CAA47851.1,
AAH69681.1,
AAB40116.1
Ensembl_TRS:
ENST00000289957
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000289957
RefSeq:
XP_011542692.1,
NP_001334646.1,
NP_000740.1
|
| Others |
UniRef100:
UniRef100_Q05901
UniRef90:
UniRef90_Q05901
UniRef50:
UniRef50_P12391
UniGene:
Hs.654576
CCDS:
CCDS6134.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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