| Type | Description |
|---|---|
| Definition | sequestosome 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 11:02:00 | Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. | 30273743 |
| 2018-08-18 11:26:00 | Data suggest that neuroprotection via ghrelin involves up-regulation of Bcl-2 (B cell lymphoma 2 associated oncogene) and p-62/Sqstm1 (ubiquitin-binding protein p62) plus down-regulation of LC3-II (microtubule-associated protein 1 light chain 3) and Beclin-1. Studies were conducted in adult hippocampal neural stem cells in primary culture. | 29057768 |
| 2018-07-14 11:13:00 | Quantifying autophagy using novel LC3B and p62 TR-FRET assays. | 29554128 |
| 2017-09-09 12:29:00 | Data suggest that phosphorylation of Sqstm1 by AMP-activated protein kinase (AMPK) and translocation of Sqstm1 to mitochondria drives autophagic cell death in adult hippocampal neural stem cells; activation of AMPK promotes autophagic cell death; inhibition of AMPK (by enzyme inhibitor or RNA interference) suppresses autophagic cell death. (Sqstm1 = sequestosome 1) | 28655770 |
| 2017-08-12 10:58:00 | p62 overexpression resulted in a progressive and robust pathology model with neuronal inclusions and neurodegeneration. | 28076378 |
| Type | IDs |
|---|---|
| Synonymous | Osi, ZIP, ZIP3 |
| Gene |
UniProtKB-ID:
SQSTM_RAT
UniprotKB:
O08623
UniParc:
UPI00000E8DF1,
UPI00005B7381,
UPI00000E5973
EMBL:
AF439403,
BC061575,
Y08355
Ensembl:
ENSRNOG00000003147
KO:
rno:113894
|
| Nucleutide sequences |
EMBL-CDS:
CAA69642.1,
AAH61575.1,
AAO15463.1
Ensembl_TRS:
ENSRNOT00000059255
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000056021
RefSeq:
XP_006246277.1,
XP_006246275.1,
NP_787037.2,
XP_006246276.1,
NP_853528.1
|
| Others |
UniRef100:
UniRef100_O08623
UniRef90:
UniRef90_O08623
UniRef50:
UniRef50_Q13501
UniGene:
Rn.107103
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员