| Type | Description |
|---|---|
| Definition | cholinergic receptor nicotinic alpha 2 subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 10:03:00 | The index variant (rs56372821) is a strong expression quantitative trait locus for CHRNA2; analyses of the genetically regulated gene expression identified a significant association of CHRNA2 expression with cannabis use disorder (CUD) in brain tissue. At the polygenic level, analyses revealed a significant decrease in the risk of CUD with increased load of variants associated with cognitive performance. | 31209380 |
| 2019-05-18 10:17:00 | These results reveal a beige-selective immune-adipose interaction mediated through CHRNA2 and identify a novel function of nicotinic acetylcholine receptors in energy metabolism. | 29785025 |
| 2018-12-22 10:50:00 | In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction. Our study suggested evidence of interactions between CHRNs in controlling the risk of NSCL/P. | 29688589 |
| 2018-01-27 11:26:00 | A crystal structure of a human neuronal CHRNA2 extracellular domain in pentameric assembly has been reported. | 27493220 |
| 2016-08-06 11:58:00 | The rare variants in CHRNA2 were significantly associated with smoking status. | 25450229 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ACHA2_HUMAN
UniprotKB:
Q15822
UniParc:
UPI000013CA9F,
UPI0001E8EFA7
EMBL:
BC153866,
Y16281,
U62431,
AF311103,
AK296348
Ensembl:
ENSG00000120903
KO:
hsa:1135
|
| Nucleutide sequences |
EMBL-CDS:
CAA76154.1,
AAB40109.1,
BAG59031.1,
AAI53867.1
Ensembl_TRS:
ENST00000407991,
ENST00000240132
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385026,
ENSP00000240132
RefSeq:
NP_001334637.1,
NP_001334636.1,
NP_001334635.1,
NP_000733.2,
NP_001334634.1,
NP_001269384.1,
XP_011542691.1
|
| Others |
UniRef100:
UniRef100_Q15822
UniRef90:
UniRef90_Q15822
UniRef50:
UniRef50_P04757
UniGene:
Hs.57718
CCDS:
CCDS6059.1,
CCDS64856.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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