| Type | Description |
|---|---|
| Definition | ATP-binding cassette, sub-family A (ABC1), member 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:28:00 | Cell-Type-Specific Complement Profiling in the ABCA4(-/-) Mouse Model of Stargardt Disease. | 33187113 |
| 2021-02-13 13:23:00 | Disentangling the Roles of RIM and Munc13 in Localization and Neurotransmission. | 33139401 |
| 2019-01-12 11:06:00 | ABCA4 functions to recycle retinaldehyde released during proteolysis of rhodopsin in retinal pigment epithelium endolysosomes following daily phagocytosis of distal photoreceptor OS. ABCA4 deficiency in the retinal pigment epithelium may play a role in the pathogenesis of Recessive Stargardt disease 1. | 30397118 |
| 2019-01-05 10:44:00 | we show that the p.Asn965Ser ABCA4 variant expresses at half the level of WT ABCA4, partially mislocalizes to the endoplasmic reticulum (ER) of photoreceptors, is devoid of N-Ret-PE activated ATPase activity, and causes an increase in autofluorescence and the bisretinoid A2E associated with lipofuscin deposits in retinal pigment epithelial cells as found in Stargardt patients and Abca4 knockout mice. | 29145636 |
| 2017-06-24 11:35:00 | a comprehensive analysis using RNA-seq identified important roles of the acute stress response in the degenerating retina of Abca4-/-Rdh8-/- mice that are predisposed to retinal degeneration under light stress. | 27315541 |
| Type | IDs |
|---|---|
| Synonymous | AW050280, Abc10, Abcr, D430003I15Rik, RmP |
| Gene |
UniProtKB-ID:
ABCA4_MOUSE
UniprotKB:
O35600
UniParc:
UPI00000299B8
EMBL:
AF000149,
BC057853
Ensembl:
ENSMUSG00000028125
KO:
mmu:11304
|
| Nucleutide sequences |
EMBL-CDS:
AAH57853.1,
AAC23916.1
Ensembl_TRS:
ENSMUST00000013995
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000013995
RefSeq:
NP_031404.1,
XP_006500975.1,
XP_006500974.1,
XP_017174928.1,
XP_017174929.1,
XP_036018752.1
|
| Others |
UniRef100:
UniRef100_O35600
UniRef90:
UniRef90_O35600
UniRef50:
UniRef50_P78363
UniGene:
Mm.3918
CCDS:
CCDS38617.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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