| Type | Description |
|---|---|
| Definition | ferredoxin 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:41:00 | By binding zinc-free ISCU, iron drives persulfide uptake from NFS1 and allows persulfide reduction into sulfide by FDX2, thereby coordinating sulfide production with its availability to generate Fe-S clusters. FXN stimulates the whole process by accelerating persulfide transfer. This reconstitution recapitulates physiological conditions which provides a model for Fe-S cluster biosynthesis on the scaffold protein ISCU. | 31395877 |
| 2019-07-20 10:14:00 | The phenotype was mapped to the same homozygous missense mutation in FDX2 (c.431C > T, p.P144L). The deleterious effect of the mutation was validated by real-time reverse transcription polymerase chain reaction and western blot analysis, which demonstrated normal expression of FDX2 mRNA but severely reduced expression of FDX2 protein in muscle tissue. | 30010796 |
| 2015-02-14 12:03:00 | Fdx2 is the second component of the Fe-S cluster biogenesis machinery, the first being IscU that is associated with isolated mitochondrial myopathy. | 24281368 |
| 2013-08-03 11:06:00 | unique conformational change is observed when holo hFd2 is warmed to physiological temperatures, or higher | 23208207 |
| 2010-12-05 22:08:00 | Observational study of gene-disease association. (HuGE Navigator) | 20877624 |
| Type | IDs |
|---|---|
| Synonymous | FDX1L |
| Gene |
UniProtKB-ID:
FDX2_HUMAN
UniprotKB:
Q6P4F2
UniParc:
UPI000007229F,
UPI000059D665
EMBL:
AK300568,
AK097022,
AC011511,
BC063460
Ensembl:
ENSG00000267673
KO:
hsa:112812
|
| Nucleutide sequences |
EMBL-CDS:
BAC04929.1,
BAH13303.1,
AAH63460.1
Ensembl_TRS:
ENST00000393708
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377311
RefSeq:
NP_001026904.2
|
| Others |
UniRef100:
UniRef100_Q6P4F2
UniRef90:
UniRef90_Q6P4F2
UniRef50:
UniRef50_Q6P4F2
UniGene:
Hs.654865
CCDS:
CCDS32905.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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