| Type | Description |
|---|---|
| Definition | POU class 6 homeobox 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 10:49:00 | Whole-genome sequencing identified two novel somatic mutations in the POU6F2 gene (c. 839 C>T; c. 875A>G) in patients with prolactinoma. The mutations obviously decreased the expression level of POU6F2. Inhibition its activity increased the cell proliferation and PRL secretion in pituitary tumor cell line, but proliferation and PRL secretion were decreased in cells with POU6F2 overexpression. | 31692290 |
| 2018-07-14 12:14:00 | We further discovered that the expression of transcription factor POU class 6 homeobox 2 (POU6F2) is restricted to Corneal endothelial cells (CECs) , and upregulated during human CEC differentiation, suggesting that POU6F2 is pivotal to terminal differentiation of CECs | 29113774 |
| 2018-06-23 11:09:00 | Genomic loci were examined in the NEIGHBORHOOD database to determine if they are potential risk factors for human glaucoma identified using meta-data from human GWAS. The top 50 hits all resided within one gene (POU6F2), with the highest significance level of p = 10-6 for SNP rs76319873. POU6F2 is found in retinal ganglion cells and in corneal limbal stem cells. | 29370175 |
| 2017-11-25 15:02:00 | Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development | 27425396 |
| 2010-09-15 22:05:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20663923 |
| Type | IDs |
|---|---|
| Synonymous | RPF-1, WT5, WTSL |
| Gene |
UniProtKB-ID:
PO6F2_HUMAN
UniprotKB:
P78424
UniParc:
UPI00001AE645,
UPI0000480E81
EMBL:
U91934,
AC011292,
AC073345,
CH236951,
AC092174,
AC005483,
U91935
Ensembl:
ENSG00000106536
KO:
hsa:11281
|
| Nucleutide sequences |
EMBL-CDS:
AAB49727.1,
AAC83404.2,
EAL23992.1,
AAP21873.1,
AAS07475.1,
AAB49728.1
Ensembl_TRS:
ENST00000403058
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384004
RefSeq:
NP_009183.3,
NP_001357888.1,
NP_001159490.1
|
| Others |
UniRef100:
UniRef100_P78424
UniRef90:
UniRef90_P78424
UniRef50:
UniRef50_P78424
UniGene:
Hs.137106
CCDS:
CCDS34620.2,
CCDS55103.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31692290 |
Identification of a novel somatic mutation of POU6F2 by whole-genome sequencing in prolactinoma. Mol Genet Genomic Med Yazhou Miao , Chuzhong Li , Jing Guo , Hongyun Wang , Lei Gong , Weiyan Xie , Yazhuo Zhang |
2019-12-01 | - |
| 29370175 |
PLoS Genet Rebecca King , Felix L Struebing , Ying Li , Jiaxing Wang , Allison Ashley Koch , Jessica N Cooke Bailey , Puya Gharahkhani , International Glaucoma Genetics Consortium , NEIGHBORHOOD Consortium , Stuart MacGregor , R Rand Allingham , Michael A Hauser , Janey L Wiggs , Eldon E Geisert |
2018-01-01 | - |
| 29113774 |
EBioMedicine Masahito Yoshihara , Susumu Hara , Motokazu Tsujikawa , Satoshi Kawasaki , Yoshihide Hayashizaki , Masayoshi Itoh , Hideya Kawaji , Kohji Nishida |
2017-11-01 | - |
| 28611215 |
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown |
2017-06-27 | - |
| 27425396 |
Int. J. Biochem. Cell Biol. Antonio Fiorino , Giacomo Manenti , Beatrice Gamba , Gabriele Bucci , Loris De Cecco , Michele Sardella , Giacomo Buscemi , Sara Ciceri , Maria T Radice , Paolo Radice , Daniela Perotti |
2016-07-15 | - |
| 23382691 |
PLoS Genet Gordan Lauc , Jennifer E Huffman , Maja PuÄiÄ , Lina Zgaga , Barbara Adamczyk , Ana MužiniÄ , Mislav Novokmet , Ozren PolaÅ¡ek , Olga Gornik , Jasminka KriÅ¡tiÄ , Toma Keser , Veronique Vitart , Blanca Scheijen , Hae-Won Uh , Mariam Molokhia , Alan Leslie Patrick , Paul McKeigue , Ivana KolÄiÄ , Ivan KreÅ¡imir LukiÄ , Olivia Swann , Frank N van Leeuwen , L Renee Ruhaak , Jeanine J Houwing-Duistermaat , P Eline Slagboom , Marian Beekman , Anton J M de Craen , André M Deelder , Qiang Zeng , Wei Wang , Nicholas D Hastie , Ulf Gyllensten , James F Wilson , Manfred Wuhrer , Alan F Wright , Pauline M Rudd , Caroline Hayward , Yurii Aulchenko , Harry Campbell , Igor Rudan |
2013-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 20663923 |
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet Richard Anney , Lambertus Klei , Dalila Pinto , Regina Regan , Judith Conroy , Tiago R Magalhaes , Catarina Correia , Brett S Abrahams , Nuala Sykes , Alistair T Pagnamenta , Joana Almeida , Elena Bacchelli , Anthony J Bailey , Gillian Baird , Agatino Battaglia , Tom Berney , Nadia Bolshakova , Sven Bölte , Patrick F Bolton , Thomas Bourgeron , Sean Brennan , Jessica Brian , Andrew R Carson , Guillermo Casallo , Jillian Casey , Su H Chu , Lynne Cochrane , Christina Corsello , Emily L Crawford , Andrew Crossett , Geraldine Dawson , Maretha de Jonge , Richard Delorme , Irene Drmic , Eftichia Duketis , Frederico Duque , Annette Estes , Penny Farrar , Bridget A Fernandez , Susan E Folstein , Eric Fombonne , Christine M Freitag , John Gilbert , Christopher Gillberg , Joseph T Glessner , Jeremy Goldberg , Jonathan Green , Stephen J Guter , Hakon Hakonarson , Elizabeth A Heron , Matthew Hill , Richard Holt , Jennifer L Howe , Gillian Hughes , Vanessa Hus , Roberta Igliozzi , Cecilia Kim , Sabine M Klauck , Alexander Kolevzon , Olena Korvatska , Vlad Kustanovich , Clara M Lajonchere , Janine A Lamb , Magdalena Laskawiec , Marion Leboyer , Ann Le Couteur , Bennett L Leventhal , Anath C Lionel , Xiao-Qing Liu , Catherine Lord , Linda Lotspeich , Sabata C Lund , Elena Maestrini , William Mahoney , Carine Mantoulan , Christian R Marshall , Helen McConachie , Christopher J McDougle , Jane McGrath , William M McMahon , Nadine M Melhem , Alison Merikangas , Ohsuke Migita , Nancy J Minshew , Ghazala K Mirza , Jeff Munson , Stanley F Nelson , Carolyn Noakes , Abdul Noor , Gudrun Nygren , Guiomar Oliveira , Katerina Papanikolaou , Jeremy R Parr , Barbara Parrini , Tara Paton , Andrew Pickles , Joseph Piven , David J Posey , Annemarie Poustka , Fritz Poustka , Aparna Prasad , Jiannis Ragoussis , Katy Renshaw , Jessica Rickaby , Wendy Roberts , Kathryn Roeder , Bernadette Roge , Michael L Rutter , Laura J Bierut , John P Rice , Jeff Salt , Katherine Sansom , Daisuke Sato , Ricardo Segurado , Lili Senman , Naisha Shah , Val C Sheffield , Latha Soorya , Inês Sousa , Vera Stoppioni , Christina Strawbridge , Raffaella Tancredi , Katherine Tansey , Bhooma Thiruvahindrapduram , Ann P Thompson , Susanne Thomson , Ana Tryfon , John Tsiantis , Herman Van Engeland , John B Vincent , Fred Volkmar , Simon Wallace , Kai Wang , Zhouzhi Wang , Thomas H Wassink , Kirsty Wing , Kerstin Wittemeyer , Shawn Wood , Brian L Yaspan , Danielle Zurawiecki , Lonnie Zwaigenbaum , Catalina Betancur , Joseph D Buxbaum , Rita M Cantor , Edwin H Cook , Hilary Coon , Michael L Cuccaro , Louise Gallagher , Daniel H Geschwind , Michael Gill , Jonathan L Haines , Judith Miller , Anthony P Monaco , John I Nurnberger , Andrew D Paterson , Margaret A Pericak-Vance , Gerard D Schellenberg , Stephen W Scherer , James S Sutcliffe , Peter Szatmari , Astrid M Vicente , Veronica J Vieland , Ellen M Wijsman , Bernie Devlin , Sean Ennis , Joachim Hallmayer |
2010-10-15 | - |
| 20201926 |
Human variation in alcohol response is influenced by variation in neuronal signaling genes. Alcohol. Clin. Exp. Res. Geoff Joslyn , Ajay Ravindranathan , Gerry Brush , Marc Schuckit , Raymond L White |
2010-05-01 |
CDH13,
LRPPRC,
CPQ,
FBLN5,
SORBS1,
PAICS,
RAD51AP1,
CPLX1,
PDE10A,
AKR1C4,
ADAMTS13,
ADAMTS8,
PTPRT,
POU6F2,
CHRM1,
CHRM2,
CHRNA1,
SYNPO,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNB4,
EFHC1,
CHRND,
CNGB1,
COL4A2,
COL4A3,
VCAN,
CNTN4,
ADRB2,
AKR1C1,
DLG1,
DLG4,
DMP1,
DYNC1I1,
DOCK2,
DSPP,
EGF,
ERCC4,
EYA2,
FAH,
FBLN2,
FBN2,
FGF5,
NLGN1,
MYO16,
FOXC2,
ERC1,
FLT3,
KIF13B,
DICER1,
OR52A1,
PDSS1,
ABL1,
GAD1,
GAD2,
GALR1,
ERC2,
OPTC,
LHX6,
NUFIP1,
GHSR,
PDE7B,
ZNF638,
GLI2,
GLRB,
PCLO,
GLUD1,
GNAS,
GOT1,
GRK5,
GRIK1,
GRIK4,
GRIN2B,
GRM4,
GRM7,
GRM8,
GSTZ1,
GUCY2D,
HGD,
HLF,
HMGA1,
HNRNPA2B1,
IRF8,
IGF1R,
IMPG1,
IDO1,
ITGA2,
ITGB2,
KCNH1,
LAMB1,
ASIC2,
MAT1A,
MATN3,
ASPA,
MSH2,
ZFHX3,
MYL5
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
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