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11269 DDX19B

11269

DDX19B

DEAD-box helicase 19B

protein-coding

Homo sapiens

基因描述

Type Description
Definition DEAD-box helicase 19B

研究结论

Date Results Publications
2021-04-03 13:34:00 Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression. 33205304
2020-11-21 13:26:00 Dbp5/DDX19 between Translational and 32041247
2019-06-22 10:28:00 Results found that Nup159 did not accelerate ADP release, while Gle1 actually slowed it independently of Mg(2+) which is not consistent with Nup159 acting as a nucleotide exchange factor to promote ADP release and Dbp5 ATPase cycling. Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found more reduced, suggesting that Nup159 alters the Dbp5-Gle1 to aid Gle1 release from Dbp5. 29782832
2018-08-04 10:43:00 These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. 29746542
2017-10-07 12:07:00 DDX19 interacts with pre-termination complexes (preTCs) in a nucleotide-dependent manner. Furthermore, DDX19 increases the efficiency of termination complex (TC) formation and the peptide release in the presence of eukaryotic release factors. DDX19 also stabilizes ribosome complexes with translation elongation factors eEF1 and eEF2. 28180304

名称对应

Type IDs
Synonymous DBP5, DDX19, RNAh
Gene
UniProtKB-ID: DD19B_HUMAN, A0A024QZ90_HUMAN, A0A0U4B4U6_HUMAN, B4DL69_HUMAN
UniprotKB: Q9UMR2, A0A024QZ90, A0A0U4B4U6, B4DL69
UniParc: UPI0000E24370, UPI0001AE685C, UPI0000037B60, UPI000006EAB6, UPI000012907F
EMBL: CR457215, KU159421, BC010008, AK316346, AC012184, AJ237946, CH471241, AL136639, AK296868, AK301938, AF353720, BC003626, AK027378, CR533509, AK302107
Ensembl: ENSG00000157349
KO: hsa:11269
Nucleutide sequences
EMBL-CDS: BAG51311.1, CAG38540.1, EAW51834.1, CAG33496.1, EAW51831.1, AAH10008.1, AAH03626.1, AAK40102.1, EAW51827.1, BAG63488.1, CAB66574.1, EAW51832.1, BAG63358.1, BAH14717.1, CAB52189.1, EAW51837.1, ALX00013.1, EAW51833.1, BAG59431.1
Gene_ORFName: hCG_1998531, hCG_1998531
Ensembl_TRS: ENST00000393657, ENST00000451014, ENST00000568625, ENST00000355992, ENST00000563392, ENST00000288071
Protein sequencees
Ensembl_PRO: ENSP00000348271, ENSP00000456574, ENSP00000377267, ENSP00000288071, ENSP00000392639, ENSP00000456757
RefSeq: NP_001350867.1, NP_001244104.1, NP_001014449.1, NP_001244102.1, NP_001014451.1, NP_001244103.1, NP_009173.1, NP_001244101.1
Others
UniRef100: UniRef100_Q9UMR2, UniRef100_H3BQK0
UniRef90: UniRef90_J9PAF3, UniRef90_Q9UMR2
UniRef50: UniRef50_Q9UMR2, UniRef50_J9PAF3
UniGene: Hs.221761
CCDS: CCDS32475.1, CCDS58478.1, CCDS10888.1, CCDS42187.1

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