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112367 Sle1

112367

Sle1

systemic lupus erythmatosus susceptibility 1

unknown

Mus musculus

基因描述

Type Description
Definition systemic lupus erythmatosus susceptibility 1

研究结论

Date Results Publications
2015-08-29 10:42:00 This study showed that estrogens, acting via ERalpha, control sex bias in the Sle1 phenotype. 25862391
2014-08-23 10:37:00 Sle1 lupus-susceptibility locus may facilitate the emergence of anti-DNA B cells by subduing BCR revision and possibly by shaping the extrafollicular development of effector B cells 24835399
2013-02-23 11:54:00 An epistatic interaction between Sle1 and the Tg7 transgenic mouse strain results in severe autoimmune pathology. 23150717
2012-09-22 10:33:00 Mice from recombinant congenic strains expressing Sle1c2 exhibit increased CD4-positive T cell intrinsic activation and susceptibility to chronic graft-versus-host disease. 22711888
2012-09-08 11:05:00 Mice of the B6.NZMSle1/Sle2/Sle3 (Sle1,2,3) lupus-prone strain also express an interferon (IFN) signature compared with non-autoimmune C57BL/6 mice. 22661089

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