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112366 Sle2

112366

Sle2

systemic lupus erythmatosus susceptibility 2

unknown

Mus musculus

基因描述

Type Description
Definition systemic lupus erythmatosus susceptibility 2

研究结论

Date Results Publications
2013-01-26 10:51:00 These results show that Sle2c1 contributes to lupus pathogenesis by affecting T cell differentiation in combination with other susceptibility loci, such as lpr. 21360506
2012-09-08 11:05:00 Mice of the B6.NZMSle1/Sle2/Sle3 (Sle1,2,3) lupus-prone strain also express an interferon (IFN) signature compared with non-autoimmune C57BL/6 mice. 22661089
2012-08-11 11:27:00 The -74C-to-T single nucleotide polymorphism (SNP) plays a functional role in decreasing p18/Inc4c expression in association with the Sle2c1 lupus susceptibility locus. 22504641
2011-10-08 10:42:00 study showed that at least two Sle2 genes are involved in the activation of anti-DNA B cells. 21270826
2011-06-18 10:35:00 The Sle2c2 locus of New Zealand Black mice contains a potent lupus susceptibility gene which suppresses T cell-induced autoimmune responses through myeloid-derived suppressor cells. 21335485

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