| Type | Description |
|---|---|
| Definition | three prime repair exonuclease 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:59:00 | Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway. | 32917881 |
| 2020-03-21 10:35:00 | Significant methylation loss at an intragenic site of TREX2 was a frequent trait in a cohort of patients with laryngeal cancer. Methylation loss correlated with increased expression of TREX2 in laryngeal tumors and improved overall survival. These data highlight a regulatory role of TREX2 DNA methylation for gene expression which might affect incidence and survival of laryngeal cancer. | 31053176 |
| 2019-09-28 12:37:00 | the scaffold subunit of TREX-2, GANP, positively regulates DNA repair through homologous recombination (HR). In contrast, DUBm adaptor subunits ENY2 and ATXNL3 are required to limit unscheduled HR. | 30054449 |
| 2016-10-01 12:38:00 | Altogether, data provide new insights in the molecular mechanisms of TREX2 activity and establish cell autonomous and non-cell autonomous functions of TREX2 in the UVB-induced skin response. | 26090614 |
| 2014-08-23 10:12:00 | human TREX-2 complex prevents genome instability, as determined by the accumulation of gamma-H2AX and 53BP1 foci and single-cell electrophoresis in cells depleted of the TREX-2 subunits PCID2, GANP and DSS1 | 24896180 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TREX2_HUMAN
UniprotKB:
Q9BQ50
UniParc:
UPI000006F0D9,
UPI000006ECFE
EMBL:
DQ145722,
AF319572,
AF319570,
AF319573,
AF319571,
AF151107
Ensembl:
ENSG00000183479
KO:
hsa:11219
|
| Nucleutide sequences |
EMBL-CDS:
AAD48776.1,
AAK07620.1,
AAK07619.1,
AAK07618.1,
AAK07617.1,
AAZ38719.1
Ensembl_TRS:
ENST00000370232,
ENST00000393862,
ENST00000370231,
ENST00000334497,
ENST00000330912,
ENST00000370212,
ENST00000338525
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000345218,
ENSP00000359252,
ENSP00000377442,
ENSP00000359251,
ENSP00000334993,
ENSP00000359231,
ENSP00000333441
RefSeq:
NP_542432.2
|
| Others |
UniRef100:
UniRef100_Q9BQ50
UniRef90:
UniRef90_Q9BQ50
UniRef50:
UniRef50_Q9BQ50
UniGene:
Hs.644635
CCDS:
CCDS35437.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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