| Type | Description |
|---|---|
| Definition | interleukin 1 receptor associated kinase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:31:00 | IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity. | 31664109 |
| 2019-10-26 11:02:00 | Findings demonstrated a distinctive role of IRAK-M in maintaining chronic Th2 airway inflammation and indicated a complex role for IRAK-M in the initiation and progression of experimental allergic asthma. | 30617222 |
| 2019-09-21 11:58:00 | TLR stimulation led to IRAKM-caspase-8-ASC complex formation, resulting in the activation of caspase-8 and IL-1beta release in microglia. | 30372424 |
| 2019-08-10 12:22:00 | Study determined that the expression of a novel circRNA, circIRAK3, was increased in metastatic breast cancer (BC) cells and predictive of BC recurrence and identified miR-3607 as a circIRAK3-associated miRNA. FOXC1 the target of miR-3607, was downregulated in circIRAK3-silenced cells and mediated circIRAK3-induced BC cell migration. FOXC1 in turn could bind to the IRAK3 promoter, triggering a positive-feedback loop. | 29803789 |
| 2018-12-22 10:50:00 | Clinical trial with house dust mite allergen challenge of asthmatic patients reveal that IRAK-M is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. | 29686383 |
| Type | IDs |
|---|---|
| Synonymous | ASRT5, IRAKM |
| Gene |
UniProtKB-ID:
IRAK3_HUMAN
UniprotKB:
Q9Y616
UniParc:
UPI000013D14A,
UPI0001881B4A
EMBL:
AF113136,
AC078889,
AC078927,
AK298645,
BC057800,
BC069388
Ensembl:
ENSG00000090376
KO:
hsa:11213
|
| Nucleutide sequences |
EMBL-CDS:
AAH57800.1,
AAH69388.1,
AAD40879.1,
BAG60819.1
Ensembl_TRS:
ENST00000261233,
ENST00000457197
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000261233,
ENSP00000409852
RefSeq:
NP_001135995.1,
NP_009130.2
|
| Others |
UniRef100:
UniRef100_Q9Y616
UniRef90:
UniRef90_Q9Y616
UniRef50:
UniRef50_Q9Y616
UniGene:
Hs.369265
CCDS:
CCDS44937.1,
CCDS8975.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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