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11202 KLK8

11202

KLK8

kallikrein related peptidase 8

protein-coding

Homo sapiens

基因描述

Type Description
Definition kallikrein related peptidase 8

研究结论

Date Results Publications
2021-02-06 13:49:00 Extracellular acidityinduced expression of Kallikreinrelated peptidases 7 and 8 is involved in increased invasiveness of gastric cancer cells. 32323843
2020-07-11 11:02:00 Blood KLK8 was a similarly strong discriminator for mild cognitive impairment but slightly weaker for Alzheimer's disease 31371645
2019-11-02 11:45:00 Study findings provide a comprehensive picture of the molecular mechanisms underlying the enzyme activity of recombinant human KLK8. Enzyme kinetics with optimized substrates showed stimulation by Ca2+ and inhibition by Zn2+, which are physiological regulators. Crystal structures of KLK8 with a ligand-free active site and with the inhibitor leupeptin explain the subsite specificity and display Ca2+ bound to the 75-loop. 30013126
2019-06-01 10:51:00 KLK8 levels are higher in female brain and female sex hormone increases KLK8 in neuronal/glial cells. Hippocampal KLK8 protein levels were drastically increased in women patients. 29505099
2018-10-13 11:54:00 Telbivudine treatment resulted in increased levels of serum KLK8 protein. Furthermore, eGFR increase was associated with body height-adjusted, post-treatment KLK8 levels 29936485

名称对应

Type IDs
Synonymous HNP, NP, NRPN, PRSS19, TADG14
Gene
UniProtKB-ID: KLK8_HUMAN, A0A0A0MQY9_HUMAN
UniprotKB: O60259, A0A0A0MQY9
UniParc: UPI0000071EA6, UPI0000070A2C, UPI000002ACDB, UPI000003751A, UPI00038313C5
EMBL: AY563062, AF095743, AY563063, AY563065, AY563059, AF243527, AY359036, AY563064, AF095742, AC011483, AY563066, AB012761, DQ267420, AB010780, AF055982, AC011473, BC040887, AY563067, AB008927, CH471135, AY563055, AY563058, AY563060, AY563057, AF251125, AY563061, AY563056, AB009849, AB008390
Ensembl: ENSG00000129455
KO: hsa:11202
Nucleutide sequences
EMBL-CDS: AAD29574.1, AAT76923.1, AAT76935.1, AAT76917.1, AAH40887.1, AAT76919.1, AAT76915.1, AAD56050.1, AAT76918.1, BAA88684.1, AAT76928.1, AAT76916.1, AAT76938.1, AAT76930.1, AAF79144.1, AAT76932.1, AAT76926.1, AAT76921.1, AAT76927.1, BAA82665.1, AAT76929.1, AAT76920.1, BAA82666.1, AAQ89395.1, ABB83339.1, AAT76914.1, AAG23254.1, AAT76924.1, AAT76933.1, AAT76925.1, AAT76913.1, AAT76922.1, EAW71962.1, BAA28676.1, AAG33361.1, AAT76937.1, AAF79145.1, AAT76936.1, AAT76934.1, AAD25979.1, BAA28673.1, AAT76931.1
Gene_ORFName: UNQ283/PRO322
Ensembl_TRS: ENST00000320838, ENST00000391806, ENST00000600767, ENST00000347619, ENST00000593490, ENST00000291726
Protein sequencees
Ensembl_PRO: ENSP00000325072, ENSP00000472016, ENSP00000341555, ENSP00000469278, ENSP00000375682, ENSP00000291726
RefSeq: NP_653090.1, NP_653089.1, NP_001268360.1, NP_009127.1, NP_653088.1
Others
UniRef100: UniRef100_A0A0A0MQY9, UniRef100_O60259
UniRef90: UniRef90_O60259
UniRef50: UniRef50_O60259
UniGene: Hs.104570
CCDS: CCDS12813.1, CCDS12815.1, CCDS12814.1, CCDS42600.1

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